Hongyun Mao

Bone-protective effects of deer-hide gelatin in cyclophosphamide-induced osteoporosis rats

Hongyun Mao, Xinyue Zhao, Shaoqin Mo, Haili Wang et autres

Chemotherapy is a cornerstone of cancer treatment, but its adverse effects, particularly those related to the cardiovascular and skeletal systems, are drawing more attention. According to studies, the PI3K/AKT signaling pathway may be involved in myelosuppression and cardiotoxicity, two types of multi-organ …

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MicroRNAs in anthracycline cardiotoxicity: biomarkers, mechanisms, and therapeutic advances

Hongyun Mao, Jing Hu, Caoyang Yu, Sicong Xie et autres

Background: Anthracycline-based chemotherapy is a highly effective treatment for numerous cancers, yet its clinical use is severely limited by cumulative, dose-dependent cardiotoxicity. MicroRNAs (miRNAs), as key post-transcriptional regulators of gene expression, play a pivotal role in the pathophysiology of cardiovascular disease, but …

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Hydrogen sulfide-mediated cardiovascular protection involved in the antihypertensive effect of the saiga antelope horn

Miao Li, Hongyun Mao, Yongqing Hua, Linxia Wang et autres

ETHNOPHARMACOLOGICAL RELEVANCE: Saiga antelope horn (SAH), derived from the male Saiga tatarica Linnaeus, has been used in China for millennia to treat hyperpyretic convulsions and hypertension-related diseases. Clarifying its effectiveness and mechanism of action are essential because of its limited availability. This …

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Identification and Integrated Analysis of Oxidative Stress-Related Genes as Potential Biomarkers for Diagnosis and Treatment of Rheumatoid Arthritis using Bioinformatics Methods

Hongyun Mao, Sicong Xie, Caoyang Yu, Yang Zhang et autres

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Hydrogen Sulfide-Mediated Cardiovascular Protection Involved in the Antihypertensive Effect of the Saiga Antelope Horn

Miao Li, Hongyun Mao, Yongqing Hua, Linxia Wang et autres

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Antioxidant 1,2,3,4,6-Penta-O-galloyl-β-D-glucose Alleviating Apoptosis and Promoting Bone Formation Is Associated with Estrogen Receptors

Yongqing Hua, Haili Wang, Tingting Chen, Yeru Zhou et autres

, which is commonly used for the treatment of osteoporosis (OP). PGG is a potent natural antioxidant, and its effects on OP remain unknown. This study aimed to investigate the effects of PGG on promoting bone formation and explore its estrogen receptor …

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Activated sympathetic nerve post stroke downregulates Toll-like receptor 5 and disrupts the gut mucosal barrier

Huidi Wang, Jie Li, Guangyan Wu, Xiaofei Lin et autres

The gut permeability significantly increases after ischemic stroke, partly due to disrupted mucosal barrier, but the mechanism remains elusive. Here, we found that the mucus disruption starts at 2 h post stroke, whereas goblet cell functions remain intact. Meanwhile, the flagellated bacteria …

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