Maggie Lee

PATH-18. Investigating the role of CDKN2A loss in IDH-mutant gliomas: biological insights beyond tumour grading

Alexander Yuile, Laveniya Satgunaseelan, Kimberley L. Alexander, Subotheni Thavaneswaran et autres

Abstract CDKN2A/B homozygous deletion (HoD) in IDH-mutant astrocytomas is associated with poor prognosis and now defines WHO grade 4 status, regardless of histology. We hypothesized that CDKN2A loss resulting from CDKN2A/B HoD drives biological changes independent of morphological grade. To explore this, …

us, au (code pays fourni par la source)

Joint reconstruction and motion correction of the fetal brain T2 maps

Suryava Bhattacharya, Anthony N. Price, Alena Uus, Helena S. Sousa et autres

Motivation: Our previously proposed pipeline for measuring T2 involves obtaining three stacks at three echo times (TE), totalling nine stacks, to produce 3D motion-corrected T2 maps. Here, we propose updates to streamline the process, reduce data requirements, and improve the usability of …

Spatially resolved transcriptomics reveals a unique disease signature and potential biomarkers for chronic traumatic encephalopathy

Catherine M. Suter, Jennifer E. Cropley, Andrew J. Affleck, Maggie Lee et autres

Chronic traumatic encephalopathy (CTE) is a poorly understood environmental tauopathy uniquely associated with repetitive head injury. It is clinically ambiguous and at present can only be diagnosed post-mortem. There is a pressing need to understand CTE pathophysiology in order to identify targets …

au (code pays fourni par la source)

Kidney Disease: Improving Global Outcomes Summit Recommendations on Implementation of Diabetes Management in CKD: From Primary to Data-Driven Collaborative Care

Philip Kam‐Tao Li, Michael Cheung, Kai‐Ming Chow, Maria Leung et autres

Type 2 diabetes and chronic kidney disease (CKD) are preventable and treatable. Their silent and progressive clinical course calls for structured assessment with timely feedback to patients and care providers for activating decision-making. Apart from CKD, patients with diabetes can have complications …

hk, cn, my, au, sg, gb, in, ca, jp, vn, tw (code pays fourni par la source)

Spatially resolved transcriptomics reveals a unique disease signature and potential biomarkers for chronic traumatic encephalopathy

Catherine M. Suter, Jennifer E. Cropley, Andrew J. Affleck, Maggie Lee et autres

Abstract Chronic traumatic encephalopathy (CTE) is a poorly understood environmental tauopathy uniquely associated with repetitive head injury. It is clinically ambiguous, and at present can only be diagnosed post-mortem. There is a pressing need to understand CTE pathophysiology in order to identify …

au (code pays fourni par la source)

Clinical outcomes and management of CDKN2A/B homozygously deleted IDH-mutant astrocytomas—a cohort study and patterns of care survey

Alexander Yuile, Laveniya Satgunaseelan, Kimberley L. Alexander, Subotheni Thavaneswaran et autres

Abstract Background The use of CDKN2A/B deletions in the current WHO CNS classification (5th edition, 2021), has led to some ambiguity in patient management. Further clinical studies are required to fully ascertain the clinical impact of CDKN2A/B deletions in this patient cohort …

au (code pays fourni par la source)

A 30-year case study of local implementation of global guidelines for data-driven diabetes management starting with the Hong Kong Diabetes Register

Juliana C.N. Chan, Michael Cheung, Andrea O. Y. Luk, Harriet Chung et autres

Diabetes and its complications, notably chronic kidney disease (CKD) are silent disease states whose risk factors and treatment targets are often characterized by numerical values, thus making regular measurements imperative in guiding medical decisions and empowering patient self-management. In 2019, we summarized …

hk, cn (code pays fourni par la source)

7542 Androgen Receptor Oligomerization State Allows Cells to Exhibit Non-Linear Dose Responses to Androgens Resulting in Distinct Biological Outputs

R. Safi, Suzanne E. Wardell, Peter Watkinson, Xuezhong Qin et autres

Abstract Disclosure: R. Safi: None. S.E. Wardell: None. P. Watkinson: None. X. Qin: None. M. Lee: None. S. Park: None. T. Krebs: None. E. Dolan: None. T. Tsuji: None. S. Nayak: None. M. Khater: None. M. Newlin: None. M. Kirkland: None. Y. …

us (code pays fourni par la source)

In-Vivo T2 measurements of fetal brain in 1.5T

Suryava Bhattacharya, Anthony N. Price, Alena Uus, Helena Tavares de Sousa et autres

Fetal brains go through rapid development, resulting in significant changes in tissue observable by MRI, during gestation. This work presents a quantitative MR imaging pipeline that aims to measure T2 relaxation in fetal brains from clinically acquired single-shot TSE sequences, reconstructed using …

‘The Reports of My Death Are Greatly Exaggerated’—Evaluating the Effect of Necrosis on MGMT Promoter Methylation Testing in High-Grade Glioma

Laveniya Satgunaseelan, Maggie Lee, S. Iannuzzi, Susannah Hallal et autres

(1) Background: MGMT (O-6-methylguanine-DNA methyltransferase) promoter methylation remains an important predictive biomarker in high-grade gliomas (HGGs). The influence of necrosis on the fidelity of MGMT promoter (MGMTp) hypermethylation testing is currently unknown. Therefore, our study aims to evaluate the effect of varying …

au (code pays fourni par la source)

In vivo T2 measurements of the fetal brain using single‐shot fast spin echo sequences

Suryava Bhattacharya, Anthony N. Price, Alena Uus, Helena S. Sousa et autres

PURPOSE: We propose a quantitative framework for motion-corrected T2 fetal brain measurements in vivo and validate the single-shot fast spin echo (SS-FSE) sequence to perform these measurements. METHODS: Stacks of two-dimensional SS-FSE slices are acquired with different echo times (TE) and motion-corrected …

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Chronic and Neurotropic: A Paradigm-Challenging Case of Dengue Virus Encephalitis in a Patient With Advanced HIV Infection

Tina Marinelli, Jeffrey Masters, Michael E. Buckland, Maggie Lee et autres

A 32-year-old female with advanced human immunodeficiency virus infection presented to an Australian hospital with subacute, worsening symptoms of encephalitis. Metagenomic sequencing and Dengue NS3 antigen staining of brain tissue confirmed active dengue virus (DENV) encephalitis. The most recent possible DENV exposure …

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