Xiaofeng Jiao

FAP promotes progression of oral leukoplakia via activation of PI3K/AKT pathway by interacting with ITGB1

Tiantian Liu, Yixuan Gu, Yuantao Gao, Xiaofeng Jiao et autres

OBJECTIVE: This study aims to elucidate the molecular mechanisms by which fibroblast activation protein (FAP) contributes to the malignant progression of oral leukoplakia (OLK). METHODS: FAP expression was assessed via immunohistochemistry in human OLK and oral squamous cell carcinoma (OSCC) tissues across …

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Heat Shock Protein 70-2 is Overexpressed in Oral Leukoplakia and Oral Squamous Cell Carcinoma

Ran Li, Xiaofeng Jiao, Yixuan Gu, Xiaotong Shi et autres

OBJECTIVE: The objective of this study was to assess the correlation between the expression of HSP70-2 and the development of oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC). Furthermore, the study evaluates the potential function of HSP70-2 in the …

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A Graphene-Based Lipid Modulation Nanoplatform for Synergetic Lipid Starvation/Chemo/Photothermal Therapy of Oral Squamous Cell Carcinoma

Ran Li, Yanwei Li, Zijian Song, Yixuan Gu et autres

Purpose: Chemotherapy is one of the most commonly used treatments for oral squamous cell carcinoma (OSCC), but its use is limited by drug resistance and severe systemic toxicity. To eliminate these side effects and improve anti-tumor efficacy, several therapeutic approaches have been …

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Nanocarrier-based drug delivery system with dual targeting and NIR/pH response for synergistic treatment of oral squamous cell carcinoma

Ran Li, Chaoqiong Wan, Yanwei Li, Xiaofeng Jiao et autres

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Expression of FAP in Oral Leukoplakia and Oral Squamous Cell Carcinoma

Ran Li, Rongrong Zhang, Xiaotong Shi, Xiaofeng Jiao et autres

OBJECTIVE: This study aimed to investigate the potential of fibroblast activation protein (FAP) as a biomarker in the progression of oral leukoplakia (OLK) carcinogenesis. This was achieved by evaluating FAP expression at different levels of the organisation, namely oral normal mucosa (NM), …

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A Targeted and pH-Responsive Nano-Graphene Oxide Nanoparticle Loaded with Doxorubicin for Synergetic Chemo-Photothermal Therapy of Oral Squamous Cell Carcinoma

Ran Li, Chen Liu, Chaoqiong Wan, Tiantian Liu et autres

Purpose: Oral squamous cell carcinoma (OSCC) is a malignant disease with serious impacts on human health and quality of life worldwide. This disease is traditionally treated through a combination of surgery, radiotherapy, and chemotherapy. However, the efficacy of traditional treatments is hindered …

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