Accès ouvert
2026
article
OpenAlex
David Taborsky, Fabiola Valdivia-Francia, Pablo Serrano, Sukalp Muzumdar et autres
Abstract The establishment of the body plan during gastrulation represents a hallmark of animal life. It emerges from the interplay of gene-regulatory programs and positional cues, yet how these signals are integrated post-transcriptionally remains largely unexplored. Here, we combine the scalability of …
ch, it
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Accès ouvert
2026
article
OpenAlex
Giulia Pagani, Chiara Casirati, Cecilia Pandini, Stefania Fornezza et autres
Abstract Background Alternative polyadenylation (APA) is increasingly recognized as a pervasive oncogenic mechanism that reshapes post-transcriptional gene regulation and promotes tumor aggressiveness. Whether APA contributes to the dysregulation of NFYA —encoding the regulatory subunit of the oncogenic transcription factor NF-Y—in prostate cancer …
it, ch, gb
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Ludovic Enkler, Trian Nuredini, Aleksei Mironov, Danilo Ritz et autres
Abstract TORC1 is a central regulator of growth, integrating inputs from kinases and signaling proteins. How TORC1 activity is regulated, is still not completely understood. The small GTPase Arf1 has been implicated in TORC1 regulation, but the underlying mechanism remains elusive. Here, …
ch
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Asier González, Meriç Ataman, Aleksei Mironov, Niels Schlusser et autres
Abstract Hepatocellular carcinoma (HCC) is one the most lethal cancer types. While infections with hepatitis B or hepatitis C viruses remain the primary risk factors for HCC development worldwide, metabolic disease-associated steatohepatitis has become the fastest growing etiology of HCC, particularly in …
es, ch, it
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
David Taborsky, Fabiola Valdivia-Francia, Neguin Ranjbar, Laura Llop-Grau et autres
The establishment of the body plan during gastrulation represents a hallmark of animal life. It emerges from the interplay of gene-regulatory programs and positional cues, yet how these signals are integrated post-transcriptionally remains largely unexplored. Here, we combine the scalability of mouse …
ch, it, us, tw
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Youngbin Moon, Christina Herrmann, Aleksei Mironov, Mihaela Zavolan
The broadly used 10X Genomics technology for single-cell RNA sequencing (scRNA-seq) captures RNA 3' ends. Thus, some reads contain part of the non-templated polyadenosine tails, providing direct evidence for the sites of 3' end cleavage and polyadenylation on the respective RNAs. Taking …
ch
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Aleksei Mironov, Lorenzo Franchitti, Shreemoyee Ghosh, Marie‐Françoise Ritz et autres
Alterations in mRNA 3’ end processing and polyadenylation are widely implicated in the biology of many cancer types, including glioblastoma (GBM), one the most aggressive tumor types. Although several RNA-binding proteins (RBPs) responsible for alternative polyadenylation (APA) were identified from functional studies …
ch, it
(code pays fourni par la source)
Accès ouvert
2024
peer-review
OpenAlex
Maria Katsantoni, Foivos Gypas, Christina Herrmann, Dominik Bürri et autres
Background RNA sequencing (RNA-seq) is a widely used technique in many scientific studies. Given the plethora of models and software packages that have been developed for processing and analyzing RNA-seq datasets, choosing the most appropriate ones is a time-consuming process that requires …
ch
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Mehmet E. Karasu, Leonard Jahnke, Brian J. Joseph, Yerkezhan Amerzhanova et autres
DNA repair is directly performed by hundreds of core factors and indirectly regulated by thousands of others. We massively expanded a CRISPR inhibition and Cas9-editing screening system to discover factors indirectly modulating homology-directed repair (HDR) in the context of ∼18,000 individual gene …
ch, us
(code pays fourni par la source)