Winfried März

Genome-wide gene-environment interaction study uncovers 162 vitamin D status variants using a precise ambient UVB measure

Rasha Shraim, Maria N Timofeeva, Cathy A. Wyse, Jos H. G. M. van Geffen et autres

Abstract Vitamin D status is influenced by genetic and environmental factors—primarily sun exposure. Using satellite weather data, we estimated an ambient UVB dose for each participant based on residential address and date of sampling. We conducted genome-wide tests in 338,977 UK Biobank …

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Regulation of nc886 (vtRNA2-1) RNAs is associated with cardiometabolic risk factors and diseases

Sonja Rajić, Thomas Delerue, Justiina Ronkainen, Ruiyuan Zhang et autres

Non-coding 886 (nc886, vtRNA2-1) is a polymorphically imprinted gene. The methylation status of this locus has been shown to be associated with periconceptional conditions, and both the methylation status and the levels of nc886 RNAs have been shown to associate with later-life …

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Homozygote familiäre Hypercholesterinämie - Teil 1

Anja Vogt, Klaus Georg Parhofer, Christoph J. Binder, Christoph F. Ebenbichler et autres

Homozygote familiäre Hypercholesterinämie - Teil 2

Klaus Georg Parhofer, Anja Vogt, Christoph J. Binder, Christoph F. Ebenbichler et autres

Associations between serum mineral concentrations and mortality by renal function in the Ludwigshafen Risk and Cardiovascular Health Study

Angela P. Moissl, Graciela E. Delgado, Marcus Edi Kleber, Bernhard K. Krämer et autres

Abstract The association of serum concentrations of minerals and phosphate with overall and cardiovascular mortality based on renal function is poorly understood. 3307 patients (average age 62.7 ± 10.6 years) in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study were grouped by …

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Haptoglobin polymorphism, vitamin E and mortality: the Ludwigshafen Risk and Cardiovascular Health Study

Graciela Delgado, Marcus Edi Kleber, Angela P. Moissl, Brigitte M. Winklhofer‐Roob et autres

Objective: In humans, haptoglobin (Hp) exists in two allelic forms, Hp1 and Hp2, that differ significantly in their ability to protect the organism from oxidative stress. It has been proposed that in patients with diabetes mellitus carriers of the Hp2-2 genotype may …

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Clinical characterization and mutation spectrum of patients with hypertriglyceridemia in a German outpatient clinic

Frieda Bardey, Lorenz Rieck, Dominik Spira, Winfried März et autres

BACKGROUND: Severe hypertriglyceridemia (HTG) has predominantly multifactorial causes (MCS). Yet a small subset of patients have the monogenetic form (FCS). It remains a challenge to distinguish patients clinically, since decompensated MCS might mimic FCS´s severity. Aim of the current study was to …

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