N Rotllan

HDL-bound microRNAs modulating cholesterol efflux and homeostasis and incidence of acute myocardial infarction: A population-based case-cohort study

Javier Hernando Redondo, Mariona Llaves, Álvaro Hernáez, Pau Berenguer et autres

ABSTRACT Background HDL particles can carry microRNAs (miRNAs), capable of regulating gene expression connected to HDL functions. Despite links to some cardiovascular risk factors, miRNA association with incident acute myocardial infarction (AMI) remains unclear. Objectives Our aim was to elucidate the association …

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Lipid metabolic alterations in cancer: Common pathophysiology with cardiovascular disease

Maria Llena-Meler, Alberto Canfrán‐Duque, Julio Madrigal‐Matute, N Rotllan

Obesity-induced chronic inflammation and lipid metabolic imbalance form a pivotal nexus linking cardiovascular disease and cancer. Dysfunctional adipose tissue establishes a pro-inflammatory environment through hypoxia-driven macrophage polarization, oxidative stress, aberrant lipid signaling, and endocrine crosstalk, mechanisms that collectively foster atherogenesis and tumor …

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Replication Data for: Sources of Essential Lipids for Mycoplasma pneumoniae via P116 to Target Liver and Atherosclerotic Lesions

Joan Carles Escolá‐Gil, N Rotllan, David Vizarraga, Marina Marcos Silva et autres

Replication Data for: " Sources of Essential Lipids for Mycoplasma pneumoniae via P116 to Target Liver and Atherosclerotic Lesions" Data of the lipid acquisition capabilities of P116 from Mycoplasma pneumoniae and which lipid species it can extract from host-derived sources. This dataset …

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Sources of essential lipids for Mycoplasma pneumoniae via P116 to target liver and atherosclerotic lesions

David Vizarraga, Marina Marcos, N Rotllan, Jesús Martín et autres

Mycoplasma pneumoniae (MPN) is a bacterial pathogen that primarily causes atypical pneumonia. It cannot synthesize certain essential lipids and therefore relies on the host for their acquisition to survive. MPN has been detected in increased amounts within ruptured atherosclerotic plaques. In this …

Mechanisms modulating foam cell formation in the arterial intima: exploring new therapeutic opportunities in atherosclerosis

Maria Teresa La Chica Lhoëst, A Martinez, L Claudi, E Garcia et autres

In recent years, the role of macrophages as the primary cell type contributing to foam cell formation and atheroma plaque development has been widely acknowledged. However, it has been long recognized that diffuse intimal thickening (DIM), which precedes the formation of early …

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