Xinan Shen

TMEM165 promotes glioblastoma progression through epithelial-mesenchymal transition-mediated invasion and temozolomide chemoresistance

Yueju Ding, Xinan Shen, Qing Wang, Zhicheng Zhang et autres

Gliomas are the most common primary malignant tumors of the central nervous system and are characterized by their highly aggressive nature and poor prognosis. This study elucidates the oncogenic role of transmembrane protein TMEM165 in glioblastoma and its therapeutic potential. Bioinformatics analysis …

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Development of a radiomics-3D deep learning fusion model for prognostic prediction in pancreatic cancer

Zheng Dou, Chenghao Lu, Xinan Shen, Chenqi Gu et autres

OBJECTIVE: With pancreatic cancer’s dismal prognosis, developing accurate predictive tools is crucial for personalized treatment. This study aims to develop and evaluate a radiomics-3D deep learning fusion model to enhance survival prediction accuracy and explore its potential for clinical risk stratification in …

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KIF4A Promotes Glioblastoma Malignant Progression and Transmission of Temozolomide Resistance in the Tumor Microenvironment via the HIF1A / VEGFA Axis

Xinan Shen, Yihan Xia, Qiliang Peng, Zhicheng Zhang et autres

BACKGROUND: Glioblastoma (GBM) represents the most prevalent primary malignant brain tumor. Temozolomide (TMZ) is the primary chemotherapeutic agent administered following surgical resection. However, the emergence of TMZ resistance in patients undergoing chemotherapy significantly diminishes its efficacy. To date, the majority of preclinical …

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KIF4A Inhibits Ferroptosis in Glioblastoma via the CHMP4B/GPX4 Axis and Promotes Temozolomide Resistance

Xinan Shen, Yihan Xia, Yongdong Li, Quanquan Guo et autres

Glioblastoma (GBM) is the most malignant primary brain tumor in adults. Temozolomide (TMZ) stands for the first-line chemotherapeutic agent against GBM. TMZ resistance is an important factor contributing to the poor prognosis of GBM, but the underlying molecular mechanisms are unclear. Previous …

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Interprofessional Team–Based Whole-Course Enteral Nutrition in the Peri–Radiation Therapy Period for Esophageal Cancer

Yuntian Shen, Yawen Zhu, Xiaoxiao Liu, Wenyi Lu et autres

BACKGROUND: Radiation therapy is the main treatment method for esophageal cancer, but its side effects are not ideal. The interprofessional team (IPT) management model has been widely applied in clinical practice; however, there are few reports on nurse-led IPT-based enteral nutrition intervention …

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LC–MS metabolomics analysis of serum metabolites during neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Qiliang Peng, Lili Jiang, Yi Shen, Yao Xu et autres

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