V. A. Yakovlev

How Does Inter-Epitope Spacer Variation Within Artificial Immunogens Based on T-Cell Epitopes of Tick-Borne Encephalitis Virus Affect Immunogenicity?

Elena V. Yakovleva, Денис Антонец, M. B. Borgoyakova, Ekaterina V. Starostina et autres

Background/Objectives: In recent years, researchers have directed considerable attention toward the activation of the T-cell response in the development of vaccines against viral infections, including the tick-borne encephalitis virus (TBEV). A particularly promising approach to developing effective and safe T-cell vaccines involves …

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Intranasal Immunization with Recombinant Hemagglutinin of Influenza A/H5 Virus Complexed with Novochizol Induces Virus-Neutralizing Antibodies and Protects Animals from Lethal Viral Challenge

Надежда Б. Рудометова, Ksenia I. Ivanova, Vladislav V. Fomenko, Andrey P. Rudometov et autres

Background: Avian influenza is a critical zoonotic infection threatening both the poultry industry and global public health. While traditional intramuscular vaccines elicit systemic immunity, they often fail to provide robust local protection at mucosal surfaces. There is thus significant interest in the …

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Intranasal Immunization with Recombinant Hemagglutinin of Influenza A/H5 Virus Complexed with Novochizol Induces Virus-Neutralizing Antibodies and Protects Animals from Lethal Viral Challenge

Nadezhda B. Rudometova, Ivanova Ki, Vladislav V. Fomenko, Andrey P. Rudometov et autres

Avian influenza is a critical zoonotic infection threatening both the poultry industry and global public health. While traditional intramuscular vaccines elicit systemic im-munity, they often fail to provide robust local protection at mucosal surfaces. There is thus significant interest in the development …

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A Naked Lyophilized mRNA Vaccine Against Seasonal Influenza, Administered by Jet Injection, Provides a Robust Response in Immunized Animals

S. V. Sharabrin, Svetlana I. Krasnikova, D. N. Kisakov, M. B. Borgoyakova et autres

Background: Seasonal influenza remains a significant public health problem, and the constant antigenic drift of viruses requires regular vaccine updates. mRNA vaccines offer a promising platform for the development of new, effective influenza vaccines. Administration of the naked mRNA vaccine using a …

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DNA-protein COVID-19 combination vaccine containing multiepitope T-cell immunogen and receptor binding domain of the SARS-CoV-2 S protein

M. B. Borgoyakova, А. П. Рудометов, Ekaterina V. Starostina, V. A. Yakovlev et autres

Introduction. During the COVID-19 pandemic, the development of preventive vaccines, including those based on new platforms, became extremely relevant. One such platform is vaccines, which combine, for example, DNA and protein components into a single vaccine. The aim of this study was …

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[Immunization of Mice with the pVAXrbd DNA Vaccine by Jet Injection Induces a Stronger Immune Response and Protection against SARS-CoV-2 Compared to Intramuscular Injection by Syringe].

D. N. Kisakov, M. B. Borgoyakova, L.A. Kisakova, Ekaterina V. Starostina et autres

During the COVID-19 pandemic, it became clear that, to ensure global health security, it is essential to have a developed platform that can be used to develop a safe, low-cost, effective vaccine quickly. DNA vaccines have several advantages over other platforms, including …

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[Needle-Free Jet-Delivered mRNA-Vaccine Encoding Influenza A(H1N1)pdm09 Hemagglutinin Protects Mice from Lethal Virus Infection].

S. V. Sharabrin, A. A. Ilyichev, D. N. Kisakov, M. B. Borgoyakova et autres

Seasonal influenza is an acute respiratory illness caused by the influenza A and B viruses that circulate worldwide. Due to high variability, new strains of the virus emerge every year. Therefore, vaccine formulation has to be revised every year. The advantages of …

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Immunogenic and Protective Properties of mRNA Vaccine Encoding Hemagglutinin of Avian Influenza A/H5N8 Virus, Delivered by Lipid Nanoparticles and Needle-Free Jet Injection

V. A. Yakovlev, Victoria R. Litvinova, Надежда Б. Рудометова, M. B. Borgoyakova et autres

Background/Objectives: The development of a vaccine against highly pathogenic avian influenza viruses subtype A/H5 is an urgent task due to concerns about its pandemic potential. Methods: In this study, we have developed an experimental mRNA vaccine, mRNA-H5, encoding a modified hemagglutinin trimer …

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Immunogenic and Protective Properties of mRNA Vaccine Encoding Hemagglutinin of Avian Influenza A/H5N8 Virus, Delivered by Lipid Nanoparticles and Needle-Free Jet Injection

V. A. Yakovlev, Victoria R. Litvinova, Надежда Б. Рудометова, M. B. Borgoyakova et autres

The development of a vaccine against highly pathogenic avian influenza A/H5 viruses is an urgent task due to concerns about its pandemic potential. Here, we have developed an experimental mRNA vaccine mRNA-H5, encoding a modified hemagglutinin trimer of influenza virus A/turkey/Stavropol/320-01/2020 (H5N8). …

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Immunogenicity of the Stabilized Env Trimer HIV-1 CRF63_02A6 Produced in Protein and DNA Vaccine Formats

Надежда Б. Рудометова, А. П. Рудометов, A. A. Fando, L. A. Kisakova et autres

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Combustion of sewage sludge in a fluidized bed of catalyst: from laboratory to the pilot plant

Yury Dubinin, N. A. Yazykov, A. P. Lyulyukin, V. A. Yakovlev

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Places, times and wintering conditions of the viviparous lizard Zootoca vivipara (Lichtenstein, 1823) (Sauria: Lacertidae) in Western Siberia

V. N. Kuranova, V. A. Yakovlev

A number of aspects of the hibernation of the viviparous lizard (Zootoca vivipara) in the Asian part of its range are analyzed. The results of our own field work for the period from 1971 to 2022 in the Altai Republic (Altai Nature …