Janae Wheeler Cull

A Highly Protective Clade 1 and 2 Cross-Reactive Pandemic Influenza Virus Vaccine Based on a 4th Generation Fully Deleted Adenoviral Vector of a Rare Serotype

Qi Yan, Richard E. Bowen, Airn E. Hartwig, Janae Wheeler Cull et autres

ABSTRACT The GreVac vaccine technology was created as a fast and flexible plug-and-play vaccine platform based on a 4th generation architecture of fully deleted (fd) helper virus-independent (hi) adenoviral (Ad) vectors. For the initial proof-of-principle studies, we at Greffex had engineered an …

us (code pays fourni par la source)

Contributors

Peter Abbink, Payal Agarwal, Niklas Arnberg, Svetlana Atasheva et autres

nl, us, se, jp, gb, hr, ca, es (code pays fourni par la source)

Systems of adenoviral gene transfer vectors moving into their fourth generation

Qi Yan, Janae Wheeler Cull, E. Bart Tarbet, Uwe D. Staerz

us (code pays fourni par la source)

A Potent Pandemic Avian Influenza Virus Vaccine Based on a 4th Generation Fully Deleted Adenoviral Vector

Qi Yan, E. Bart Tarbet, Janae Wheeler Cull, Xianghua Zhang et autres

The GreVac system was developed as a fast and flexible plug-and-play vaccine platform based on an architecture of fully deleted (fd) helper virus-independent (hi) adenoviral (Ad) vectors. The present study established the potency of the GreVac technology. It demonstrated that the GreFluVie5 …

us, in (code pays fourni par la source)

The Flexible, Versatile and Fast GreGT Platform of Fully Deleted Helper-Virus Independent Adenoviral Vectors

Qi Yan, Xianghua Zhang, Janae Wheeler Cull, C. T. C. Wall et autres

ABSTRACT Gene transfer (GT) vectors have diverse applications. They have been used to restore cellular activities by reconstituting normal cellular functions, by delivering therapeutic compounds, and by priming immune responses as genetic vaccines. Viruses, nature’s gene delivery vehicles, have formed the basis …

in (code pays fourni par la source)

Protecting Allogeneic Pancreatic Islet Grafts by Engineered Veto

Yan Qi, Xianghua Zhang, Janae Wheeler Cull, Patrick J. McCoy et autres

Summary In today’s clinical practice, general immune suppression regimens are used to prevent transplant rejection. Though highly effective, they impair a patient’s protection against infectious challenges. Strategies are being sought that prevent graft rejection without inhibiting beneficial immune functions. One such approach …

us (code pays fourni par la source)

The Flexible, Versatile and Fast GreGT Platform of Fully Deleted Helper-Virus Independent Adenoviral Vectors

Qi Yan, Xianghua Zhang, Janae Wheeler Cull, C. T. C. Wall et autres

Gene transfer (GT) vectors have diverse applications. They have been used to restore cellular activities by reconstituting normal cellular functions, by delivering therapeutic compounds, and by priming immune responses as genetic vaccines. Viruses, nature's gene delivery vehicles, have formed the basis of …