Tanya T. Dang

Self‐Amplifying mRNA Enhances Transamniotic Fetal mRNA Delivery

Alex L. Huang, Emily M. Scire, Tanya T. Dang, Eva Zacharakis et autres

Intraamniotic injection of encapsulated linear mRNA routes to the fetus after placental uptake but has a limited half-life and translation. Self-amplifying mRNA (saRNA) is a synthetic mRNA containing a replicase sequence and gene of interest (GOI) with replicase-targeting motifs that allow for …

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Self-amplifying mRNA enhances transamniotic fetal mRNA delivery

Alex L. Huang, Emily M. Scire, Tanya T. Dang, Eva Zacharakis et autres

Transamniotic fetal mRNA vaccination: Active immunization against Zika virus in a rodent model

Emily M. Scire, Alex L. Huang, Thais Boccia, Ina Kycia et autres

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Prenatal administration of Immunoglobulin-M (IgM) via transamniotic fetal immunotherapy (TRAFIT)

Alex L. Huang, Emily M. Scire, Tanya T. Dang, Melody Tai et autres

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Native amniotic fluid mesenchymal stem cell response in a model of fetal growth restriction

Abbie E. Naus, Kamila Moskowitzova, Ashlyn E. Whitlock, Ina Kycia et autres

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Combined transamniotic delivery of surfactant proteins B and C mRNA enhances preterm fetal surfactant production in a rodent model

Kamila Moskowitzova, Emily M. Scire, Tanya T. Dang, Beatriz S. Bechara et autres

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Sustained early postnatal humoral and cellular immunity against human cytomegalovirus after transamniotic fetal mRNA vaccination in a rodent model

Emily M. Scire, Thais Boccia, Kamila Moskowitzova, Ina Kycia et autres

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Transamniotic fetal delivery of recombinant human immunoglobulin monoclonal antibodies: A potential novel strategy for prevention of neonatal Respiratory Syncytial Virus (RSV) disease

Emily M. Scire, Tanya T. Dang, M. Eric Tai, Eva Zacharakis et autres

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Transamniotic Delivery of Coagulation Factor VIII mRNA: A Step Toward a Potential Novel Strategy for the Perinatal Management of Hemophilia A

Kamila Moskowitzova, Emily M. Scire, Tanya T. Dang, Beatriz S. Bechara et autres

ABSTRACT Hemophilia A is an X‐linked monogenic disease resulting in insufficient pro‐coagulant factor VIII (FVIII) levels. Hemophiliac infants are at risk for life‐threatening hemorrhage, especially during birth. No perinatal treatment for Hemophilia A is currently available. It has been previously shown that …

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Transamniotic Fetal Delivery of Human Alpha‐1 Antitrypsin mRNA in a Healthy Rodent Model

Abbie E. Naus, Kamila Moskowitzova, Shuqi B. Lin, Tanya T. Dang et autres

Alpha-1 antitrypsin deficiency (AATD) can manifest at any age, including the perinatal period. Its manifestations include obstructive lung disease, which can be severe and for which current therapies are of limited benefit. We sought to determine whether the transamniotic route could be …

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Transamniotic Delivery of Hematopoietic Stem Cells Genetically Modified to Carry a Human Hemoglobin Subunit Beta Gene (HBB) in a Healthy Rodent Model

Kamila Moskowitzova, Emily M. Scire, Ina Kycia, Tanya T. Dang et autres

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Perinatal Vaccination by Transamniotic Fetal mRNA Delivery: Immunization Against Human Cytomegalovirus in a Rodent Model

Kamila Moskowitzova, Abbie E. Naus, Savas T. Tsikis, Tanya T. Dang et autres

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