Abdul Wasay Sherazi

A systematic review on clinical pharmacokinetics and pharmacodynamics of antiangiogenic tyrosine kinase inhibitors (TKIs) with high TDM scores

Abdul Wasay Sherazi, Muhammad Fawad Rasool, Zheng Jiao, Faleh Alqahtani

Tyrosine kinase inhibitor (TKI) drugs are used to treat various cancer types. This systematic review evaluates the published pharmacokinetic (PK) and pharmacodynamic (PD) parameters of TKI drugs with high therapeutic drug monitoring (TDM) scores in humans. A comprehensive computerized literature search of …

A systematic review on clinical pharmacokinetics and pharmacodynamics of antiangiogenic tyrosine kinase inhibitors (TKIs) with high TDM scores

Abdul Wasay Sherazi, Muhammad Fawad Rasool, Zheng Jiao, Faleh Alqahtani

Tyrosine kinase inhibitor (TKI) drugs are used to treat various cancer types. This systematic review evaluates the published pharmacokinetic (PK) and pharmacodynamic (PD) parameters of TKI drugs with high therapeutic drug monitoring (TDM) scores in humans. A comprehensive computerized literature search of …

A systematic review on clinical pharmacokinetics and pharmacodynamics of antiangiogenic tyrosine kinase inhibitors (TKIs) with high TDM scores

Abdul Wasay Sherazi, Muhammad Fawad Rasool, Zheng Jiao, Faleh Alqahtani

Introduction Tyrosine kinase inhibitor (TKI) drugs are used to treat various cancer types. This systematic review evaluates the published pharmacokinetic (PK) and pharmacodynamic (PD) parameters of TKI drugs with high therapeutic drug monitoring (TDM) scores in humans.Methods A comprehensive computerized literature search …

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Challenges in Validating Population Pharmacokinetic Models for Clozapine Dosage Prediction and Therapeutic Drug Monitoring: Erratum

Abdul Wasay Sherazi

In the April 2025 issue of Therapeutic Drug Monitoring, in the Letter to the Editor, “Challenges in Validating Population Pharmacokinetic Models for Clozapine Dosage Prediction and Therapeutic Drug Monitoring,”1 by Sherazi, a reference citation is missing. The above-mentioned publication describes 3 clinical …

Optimizing the Clinical Exposure of Fosfomycin in Critically Ill Adult Septic Patients: A Physiologically Based Pharmacokinetic Modeling

Abdul Wasay Sherazi

BACKGROUND: Sepsis, a condition characterized by the excessive release of inflammatory mediators, significantly alters body composition and physiology and is potentially altered by intensive care therapy. The present study aimed to expand a comprehensive physiologically based pharmacokinetic (PBPK) model for healthy individuals …

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Challenges in Validating Population Pharmacokinetic Models for Clozapine Dosage Prediction and Therapeutic Drug Monitoring

Abdul Wasay Sherazi

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A Systematic Critical Review of Clinical Pharmacokinetics of Torasemide

Abdul Wasay Sherazi, Ammara Zamir, Anees ur Rehman, Waseem Ashraf et autres

PURPOSE: Torasemide is a potassium-sparing loop diuretic used to treat fluid retention associated with congestive heart failure and kidney and hepatic diseases. This systematic review was conducted to combine all accessible data on the pharmacokinetics (PK) of torasemide in healthy and diseased …

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