J. Kawakami

N-acetylcysteine attenuates oxidative-stress-associated apoptosis and collagen deposition after rat hindlimb ischemia-reperfusion injury

Hideto Matsunaga, Ryuji Yonemitsu, Katsumasa Ideo, Junnosuke Ide et autres

Proper use of fingers and limbs is crucial for people to carry out normal activities of daily living. Therefore, when fingers or limbs are severed accidentally, replantation is attempted whenever possible. However, even when replantation is successful and fingers or limbs are …

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Giant cell tumor of bone inhibits osteoblastogenesis via WNT5B

Masaki Shimada, Tomonori Tsuyama, Naoto Yoshimura, Makoto Tateyama et autres

INTRODUCTION: Giant cell tumor of bone (GCTB) induces overproduction of bone-resorbing osteoclasts through receptor activator of nuclear factor kappa B ligand (RANKL), leading to bone resorption and destruction. Consequently, denosumab, a neutralizing antibody against RANKL (a cytokine essential for osteoclast induction), is …

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Enthesis-related progenitors recruited from the subacromial bursa contribute to rotator cuff healing in rats

Shuntaro Tanimura, Takuya Tokunaga, J. Kawakami, Tian Xiao et autres

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Aging negatively affects postoperative recovery of biomechanical strength through decreased recruitment of scleraxis+/SRY-box-containing gene 9+ enthesis-related progenitors after rotator cuff repair in rats

Shuntaro Tanimura, Takuya Tokunaga, Yuko Fukuma, J. Kawakami et autres

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ラット前十字靭帯再建術モデルにおいて遺残組織温存は早期力学強度を向上し移植腱内のScleraxis発現細胞を増加させる

J. Kawakami

The IL-17-IL-17RA axis is required to promote osteosarcoma progression in mice

Naoto Yoshimura, Ryusho Kariya, Masaki Shimada, Makoto Tateyama et autres

Osteosarcoma is rare but is the most common bone tumor. Diagnostic tools such as magnetic resonance imaging development of chemotherapeutic agents have increased the survival rate in osteosarcoma patients, although 5-year survival has plateaued at 70%. Thus, development of new treatment approaches …

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Cartilage tissues regulate systemic aging via ectonucleotide pyrophosphatase/phosphodiesterase 1 in mice

Takahiro Arima, Kazuki Sugimoto, Takuya Taniwaki, Kazuya Maeda et autres

Aging presents fundamental health concerns worldwide; however, mechanisms underlying how aging is regulated are not fully understood. Here, we show that cartilage regulates aging by controlling phosphate metabolism via ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1). We newly established an Enpp1 reporter mouse, in which …

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Transthyretin amyloid deposition in ligamentum flavum (LF) is significantly correlated with LF and epidural fat hypertrophy in patients with lumbar spinal stenosis

Kazuya Maeda, Kazuki Sugimoto, Masayoshi Tasaki, Takuya Taniwaki et autres

Lumbar spinal stenosis (LSS) is a degenerative disease characterized by intermittent claudication and numbness in the lower extremities. These symptoms are caused by the compression of nerve tissue in the lumbar spinal canal. Ligamentum flavum (LF) hypertrophy and spinal epidural lipomatosis in …

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Remnant tissue enhances early postoperative biomechanical strength and infiltration of Scleraxis-positive cells within the grafted tendon in a rat anterior cruciate ligament reconstruction model

J. Kawakami, Satoshi Hisanaga, Yuki Yoshimoto, Tomoji Mashimo et autres

When ruptured, ligaments and tendons have limited self-repair capacity and rarely heal spontaneously. In the knee, the Anterior Cruciate Ligament (ACL) often ruptures during sports activities, causing functional impairment and requiring surgery using tendon grafts. Patients with insufficient time to recover before …

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Increased plasma drug concentration and decreased additional insulin secretion following oral administration of glimepiride in Spontaneously Diabetic Torii rats

Motoyasu Miura, S. Tanaka, Murasaki Ikeda, J. Kawakami et autres

We aimed to evaluate the pharmacokinetics and pharmacological effects of glimepiride in the Spontaneously Diabetic Torii (SDT) rat, which is a non-obese model of type 2 diabetes. After oral administration of glimepiride (10 mg/kg), the maximum plasma concentrations and the area under …

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Impact of CYP2D6 Phenotype on Tramadol Pharmacokinetics and Metabolic Pathways In Cancer Patients

H. Tanaka, Takafumi Naito, Hajime Sato, J. Kawakami

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Relationship Between the Oxycodone Pharmacokinetics and Plasma 4β-Hydroxycholesterol in Cachectic Cancer Patients

Hajime Satō, Takafumi Naito, H. Tanaka, J. Kawakami

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