Runchu Zhao

Bruton's tyrosine kinase inhibitor BTKi-2 inhibits mpox virus and vaccinia virus infection

Chen Yang, Runchu Zhao, Shuting Huo, Yu Zhang et autres

ABSTRACT The recent global outbreak of mpox virus (MPXV) infections underscores the urgent need for antiviral therapies against orthopoxviruses. In this study, using a high-content screening (HCS) platform based on a modified vaccinia virus Tiantan strain with GFP insertion (MVTT-GFP) under BSL-2 …

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Anti-M1R/B6R antibody characterization and bispecific design for enhanced orthopoxvirus protection

Runchu Zhao, Lili Wu, Yi Zhang, Jianrong Ma et autres

The global outbreak of the mpox in humans, caused by the mpox virus (MPXV), underscores the urgent need for safe and effective therapeutics. In this study, we characterized the dominant MPXV immunogens, M1R and B6R, by sequencing monoclonal antibodies (MAbs) from the …

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Two noncompeting human neutralizing antibodies targeting MPXV B6 show protective effects against orthopoxvirus infections

Runchu Zhao, Lili Wu, Junqing Sun, Dezhi Liu et autres

The recent outbreak of mpox epidemic, caused by monkeypox virus (MPXV), poses a new threat to global public health. Here, we initially assessed the preexisting antibody level to the MPXV B6 protein in vaccinia vaccinees born before the end of the immunization …

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Molecular basis of hippopotamus ACE2 binding to SARS-CoV-2

Ruirui Yang, Pu Han, Pengcheng Han, Dedong Li et autres

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a wide range of hosts, including hippopotami, which are semi-aquatic mammals and phylogenetically closely related to Cetacea. In this study, we characterized the binding properties of hippopotamus angiotensin-converting enzyme 2 (hiACE2) to the spike …

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Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2

Xia Rao, Runchu Zhao, Zhou Tong, Shuxin Guo et autres

Currently, monoclonal antibodies (MAbs) targeting the SARS-CoV-2 receptor binding domain (RBD) of spike (S) protein are classified into seven classes based on their binding epitopes. However, most of these antibodies are seriously impaired by SARS-CoV-2 Omicron and its subvariants, especially the recent …

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VH-CH1 switch region-inserting multispecific antibody designs and their efficacy against SARS-CoV-2 in vitro and in vivo

Lili Wu, Yue Gao, Dandan Yu, Sheng Liu et autres

To combat SARS-CoV-2 infection, numerous monoclonal antibodies have been developed. However, the virus’s continuous variation has rendered most antibodies ineffective 1 , 2 . Although there are broad-spectrum antibodies targeting conserved epitopes on the spike (S) proteins, their neutralizing potency is generally …

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Cross-species recognition of bat coronavirus RsYN04 and cross-reaction of SARS-CoV-2 antibodies against the virus

Runchu Zhao, Sheng Niu, Pu Han, Yue Gao et autres

Following the outbreak of coronavirus disease 2019 (COVID-19), several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related coronaviruses have been discovered. Previous research has identified a novel lineage of SARS-CoV-2-related CoVs in bats, including RsYN04, which recognizes human angiotensin-converting enzyme 2 (ACE2) and …

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Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals

Shihua Li, Ruirui Yang, Di Zhang, Pu Han et autres

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has an extremely broad host range that includes hippopotami, which are phylogenetically closely related to whales. The cellular ACE2 receptor is one of the key determinants of the host range. Here, we found that ACE2s …

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Atlas of currently available human neutralizing antibodies against SARS-CoV-2 and escape by Omicron sub-variants BA.1/BA.1.1/BA.2/BA.3

Min Huang, Lili Wu, Anqi Zheng, Yufeng Xie et autres

SARS-CoV-2 Omicron variant has presented significant challenges to current antibodies and vaccines. Herein, we systematically compared the efficacy of 50 human monoclonal antibodies (mAbs), covering the seven identified epitope classes of the SARS-CoV-2 RBD, against Omicron sub-variants BA.1, BA.1.1, BA.2, and BA.3. …

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Atlas of Currently-Available Human MAbs and Escape to Newly-Emerging Omicron BA.1/BA.1.1/BA.2/BA.3

Min Mei Huang, Lili Wu, Anqi Zheng, Yufeng Xie et autres

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MD simulation of hundred-billion-metal-atom cascade collision on Sunway Taihulight

Genshen Chu, Yang Li, Runchu Zhao, Shuai Ren et autres

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MD Simulation of Hundred-Billion-Metal-Atom Cascade Collision on Sunway Taihulight

Genshen Chu, Yang Li, Runchu Zhao, Shuai Ren et autres

Radiation damage to the steel material of reactor pressure vessels is a major threat to the nuclear reactor safety. It is caused by the metal atom cascade collision, initialized when the atoms are struck by a high-energy neutron. The paper presents MISA-MD, …

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