J. Kean

Fibrin-rich environment drives catheter-associated UTIs by suppressing macrophage defenses

Armando M. Marrufo, Christopher Gager, Jonathan Molina, Marissa J. Andersen et autres

Catheter-associated urinary tract infections (CAUTIs) pose severe clinical challenges, often leading to urosepsis and multidrug resistance. The wound-healing process triggered by catheter-induced bladder damage deposits fibrinogen and its polymerized form, fibrin. However, uropathogens exploit the fibrinogen and fibrin matrix to form a …

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The PI3K-Akt pathway is a multifaceted regulator of the macrophage response to diverse group B Streptococcus isolates

Yadira S. De-Leon-Lopez, Michelle E. Thompson, J. Kean, Rebecca A. Flaherty

, is a common member of the microbial flora in healthy individuals. However, problems may arise when GBS-colonized mothers become pregnant. GBS may be transferred from a colonized mother to her newborn or developing fetus, which may result in complications such as …

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Crystal structure of the human CC chemokine receptor type 9 (CCR9) in complex with vercirnon

Christine Oswald, Mathieu Rappas, J. Kean, A.S. Dore et autres

The Cryo-Electron Microscopy Structure of the CorA channel from Methanocaldococcus jannaschii at 21.6 Angstrom in low magnesium.

Robert M. Cleverley, J. Kean, C.A. Shintre, Clair Baldock et autres

electron microscopy map, based on sample: CorA channel from Methanocaldococcus jannaschii

Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395

Kaspar Hollenstein, J. Kean, Andrea Bortolato, Rong Cheng et autres

Water Spin Temperatures and Production Rates in Several Comets Observed with NIRSPEC at Keck 2

B. P. Bonev, L. Paganini, G. L. Villanueva, M. A. DiSanti et autres

Ion channels as targets for structural study : the corA Mg²⁺ transport channel of Methanococcus jannaschii.

J. Kean

Selection of membrane protein targets for crystallization using PFO-PAGE electrophoresis

Robert M. Cleverley, Muhammad Saleem, J. Kean, Robert C. Ford et autres

A method to rapidly assess the oligomeric composition of multimeric proteins is notably absent from reported schemes for high throughput production and crystallization of membrane proteins. In this report we have investigated the suitability of PFO-PAGE electrophoresis for this purpose and present …

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