Durai Prabhu

Epidemiology and Treatment Outcomes of Diffuse Large B-Cell Lymphoma in Elderly Indian Patients: A Retrospective Study from South India

Kishore Kumar, Chezhian Subash, Durai Prabhu, Kiran Varma C A et autres

Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL) affecting the elderly population, constituting a significant proportion of lymphoma cases in this demographic. With India's aging population on the rise, it is crucial to understand the …

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Clinical Efficacy of Azacitidine Monotherapy in Elderly Acute Myeloid Leukemia Patients: A Retrospective Analysis from Chennai, India

Kishore Kumar, Durai Prabhu, Kiran Varma C A, Praveen Palanisamy et autres

Abstract Acute Myeloid Leukemia (AML) predominantly affects older adults, many of whom cannot withstand intensive chemotherapy (IC) regimens. The role of epigenetic dysregulation in AML pathogenesis has led to the use of hypomethylating agents (HMAs) like azacitidine (AZA) as alternative treatment options. …

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Hodgkin Lymphoma - Mitigating Toxicity While Preserving Cure - Eight Year Data from MIOT International, Chennai, India

Kishore Kumar, Chezhian Subash, Durai Prabhu, R. C. Manikandan

Background One of the most treatable cancers, Hodgkin's lymphoma (HL), has a 5-year survival rate of approximately 85%.We still see relapse and refractoriness in a tiny percentage of patients despite the fact that our disease is largely curable, and we also have …

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Syzygium cumini ameliorates high fat diet induced glucose intolerance, insulin resistance, weight gain, hepatic injury and nephrotoxicity through modulation of PTP1B and PPARγ signaling

Thiyagarajan Gopal, Padmanaban Muthukumaran, Durai Prabhu, Muthuswamy Balasubramanyam et autres

Metabolic disorders are majorly associated with insulin resistance and an impaired glucose tolerance. Since, many of the currently available drugs exhibit adverse effects and are resistant to therapies, natural products are a promising alternate in the alleviation of complex metabolic disorders. In …

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Low Dose Ruxolitinib in Indian Haplo-Identical Transplant Patients with Steroid Refractory Acute Graft Versus Host Disease

Kishore Kumar, Durai Prabhu, Mani Kandan, Sen Thooran et autres

Background: The number of allogeneic bone marrow transplants done in India is increasing by year. Unlike west, this region had got its own unique complications in the post-transplant period especially multi drug resistant gram negative bacterial sepsis reflecting in a higher transplant …

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Experience of Low Dose (25mg/Kg) of Cyclophosphamide (Chennai-Chezhian-Kishore PTCy Protocol) As Post Transplant Cyclophosphamide (PTCy) Dose in Haploidentical Bone Marrow Transplant

Kishore Kumar, Chezhian Subash, Durai Prabhu, Bhagavathy Subramanian et autres

Abstract Introduction:- Haploidentical Bone marrow transplantation has become one of the most commonly employed alternative donor techniques, with many centers applying T-cell-replete strategies developed by the Baltimore group using high-dose post-transplant cyclophosphamide. The usefulness of this technique is to reduce graft acquisition …

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Pattern of Bacterial Infections in Indian Bone Marrow Transplant Patients - Experience from Chennai India

Kishore Kumar, Chezhian Subash, Durai Prabhu, Dilshada Pulikkal et autres

Abstract Introduction: Bone marrow transplant, both Autograft and Allograft produces profound immune-suppression and breach of mucosal surfaces leading to many opportunistic infections. There is a difference between infection pattern in countries like India compared to western countries. The western literature is more …

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How We Did Bone Marrow Transplants amidst the COVID19 Pandemic

Kishore Kumar, Durai Prabhu, Dharani Devi, Dilshada Pulikkal et autres

Introduction COVID19 is the most heard name for the last six months, and the situation seems to worsen now. This pandemic has created significant stress on the healthcare system. Most of the resources are being diverted to COVID care, and care of …

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Augmentation of histone deacetylase 3 (HDAC3) epigenetic signature at the interface of proinflammation and insulin resistance in patients with type 2 diabetes

Sathishkumar Chandrakumar, Prabu Paramasivam, Mahalingam Balakumar, Raji Rajesh Lenin et autres

A role of proinflammation has been implicated in the pathogenesis of diabetes, but the up-stream regulatory signals and molecular signatures are poorly understood. While histone modifications such as changes in histone deacetylase (HDAC) are emerging as novel epigenetic biomarkers, there is lack …

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Improvement in glucose tolerance and insulin sensitivity by probiotic strains of Indian gut origin in high-fat diet-fed C57BL/6J mice

Mahalingam Balakumar, Durai Prabhu, Sathishkumar Chandrakumar, Prabu Paramasivam et autres

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Benefits of early glycemic control by insulin on sensory neuropathy and cataract in diabetic rats.

Mahalingam Balakumar, Natarajan Saravanan, Durai Prabhu, Bhaskaran Regin et autres

While there is an emphasis on the early glycemic control for its long-term benefits in preventing microvascular complications of diabetes, the biochemical mechanisms responsible for the long-lasting effects are not clearly understood. Therefore the impact of early insulin (EI) versus late insulin …

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