S. Russ

Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution

Evan Pepper-Tunick, Vivek Srinivas, Fred D. Mast, Song Li et autres

Abstract The rapid emergence of multidrug-resistant Mycobacterium tuberculosis (Mtb) threatens global TB control, yet the mechanisms enabling rapid evolution of drug resistance in Mtb remain poorly understood. Here we reveal that pre-existing mutations in oxidative stress response genes create permissive genomic backgrounds …

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Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution

Nitin S. Baliga, Evan Pepper-Tunick, Vivek Srinivas, Fred D. Mast et autres

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Hybridization-encoded DNA tags with paper-based readout for anti-forgery raw material tracking

Alex Crown, Peter Ney, Sergey Yekhanin, Aditi Partap et autres

Tracking and tracing raw materials is crucial for securing global supply chains. Conventional methods like barcodes and Radio Frequency Identification (RFID) tags are effective but fall short in ensuring raw material traceability and anti-counterfeiting. This work introduces DNA as a powerful tool …

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Tissue gene expression profiles and communication networks inform candidate blood biomarker identification in psoriasis and atopic dermatitis

Jamie Soul, Enar Carlsson, Sigrun R. Hofmann, S. Russ et autres

Overlapping clinical and pathomechanistic features can complicate the diagnosis and treatment of inflammatory skin diseases, including psoriasis and atopic dermatitis (AD). Spatial transcriptomics allows the identification of disease- and cell-specific molecular signatures that may advance biomarker development and future treatments. This study …

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[Neoehrlichiosis has entered the Stockholm region].

Hedvig Glans, Karin Gunnarsson, S. Russ

The number of cases diagnosed with neoehrlichiosis in Stockholm has increased over the last years. PCR analysis is needed for the detection of the intracellular bacterium Neoehrlichia mikurensis. The real number of cases in the area is unknown since the specific PCR …

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OP0100 DNA METHYLATION PATTERNS IN CD4+ T CELLS DISCERN SKIN PSORIASIS FROM PSORIATIC ARTHRITIS

Valentina Natoli, Amandine Charras, Sigrun R. Hofmann, Sarah Northey et autres

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Cell-Mediated Immune Responses and Immunopathogenesis of Human Tick-Borne Encephalitis Virus-Infection

Kim Blom, Angélica Cuapio, John Tyler Sandberg, Renata Varnaitė et autres

family. TBEV is transmitted to humans primarily from infected ticks. The virus causes tick-borne encephalitis (TBE), an acute viral disease that affects the central nervous system (CNS). Infection can lead to acute neurological symptoms of significant severity due to meningitis or meningo(myelo)encephalitis. …

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Enzymatically inactive procaspase-1 stabilizes the ASC-pyroptosome

Robert Stein, MC Heymann, Franz Kapplusch, S. Russ et autres

Caspase-1 (or interleukin-1 converting enzyme, ICE) plays an important role in mediating proinflammatory innate immune responses, especially by activation of pro-IL-1ß within inflammasomes. Some patients with recurrent febrile episodes and systemic inflammation of yet unknown origin harbor CASP1 -mutations with incomplete penetrance. …

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Generation of inducible immortalized bone marrow derived cell lines expressing mutant procaspase-1 C284A on a caspase-1 knock-out background

Franz Kapplusch, Franziska Kulling, Sören Reinke, Michael C. Heymann et autres

Caspase-1, belonging to the family of cystein proteases, is well-known for its involvement in IL-1β and IL-18 maturation. Although, caspase-1 is one of the best described caspase-family-members, open questions concerning autoinflammatory diseases, caused by procaspase-1 variants (e.g. ICE-Fever), remain. ICE-Fever patients suffer …

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Influence of the naturally occurring human CASP1 variant L265S on subcellular distribution and pyroptosis

S Rabe, MC Heymann, Robert Stein, Franz Kapplusch et autres

Patients with unexplained recurrent febrile episodes and CASP1 variants suffer from systemic sterile inflammation despite altered enzymatic activity of procaspase-1 and reduced IL-1β release. Most recent findings from our group indicate that the proinflammatory effects of CASP1 variants with reduced or abrogated …

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PW03-027 - CASP1 variants and live cell imaging

S Rabe, MC Heymann, S. Russ, Stefan Winkler et autres

Patients with unexplained recurrent febrile episodes and CASP1 variants suffer from systemic sterile inflammation despite reduced secretion of IL-1ß. As previously demonstrated by our group CASP1 variants lead to reduced enzymatic activity of procaspase-1 by destabilizing the tertiary structure of the caspase-1 …

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Resistance to Tumour Grafts Produced by a Cell-free Tumour Extract

S. Russ, G.M. Scott

A cell-free fluid has been extracted from rapidly growing J.R.S. tumours which can stimulate tumour growth when it is injected into normal rats. If the fluid is extracted from a shrinking tumour, either one doing so spontaneously or as the result of …

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