James D. Ormes

Back Cover Image, Volume 121, Number 5, May 2024

Yixiao Zhang, Sri Ranganayaki Madabhushi, Tiffany Pooi Ling Tang, Hassan Raza et autres

The cover image is based on the Research Article Contributions of Chinese hamster ovary cell derived extracellular vesicles and other cellular materials to hollow fiber filter fouling during perfusion manufacturing of monoclonal antibodies by Yixiao Zhang et al., https://doi.org/10.1002/bit.28674.

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Contributions of Chinese hamster ovary cell derived extracellular vesicles and other cellular materials to hollow fiber filter fouling during perfusion manufacturing of monoclonal antibodies

Yixiao Zhang, Sri Ranganayaki Madabhushi, Tiffany Pooi Ling Tang, Hassan Raza et autres

Hollow fiber filter fouling is a common issue plaguing perfusion production process for biologics therapeutics, but the nature of filter foulant has been elusive. Here we studied cell culture materials especially Chinese hamster ovary (CHO) cell-derived extracellular vesicles in perfusion process to …

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Direct visualization of the drug release process of non-conductive polymeric implants via molecular imaging

Zhidan Liang, Morgan B. Giles, Mallory J. Stenslik, Maureen Marsales et autres

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High Bulk-Density Amorphous Dispersions to Enable Direct Compression of Reduced Tablet Size Amorphous Dosage Units

Derek S. Frank, Haichen Nie, Anagha Chandra, Alexander Coelho et autres

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Effect of drug incorporation and polymer properties on the characteristics of electrospun nanofibers for drug delivery

Madeline B. Gelb, Ashish Punia, Shari Sellers, Parul Kadakia et autres

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Drug Release and Nanodroplet Formation from Amorphous Solid Dispersions: Insight into the Roles of Drug Physicochemical Properties and Polymer Selection

Ruochen Yang, Amanda K. P. Mann, Tu Van Duong, James D. Ormes et autres

Dissolution of amorphous solid dispersions (ASD) can lead to the formation of amorphous drug-rich nano species (nanodroplets) via liquid–liquid phase separation or glass–liquid phase separation when the drug concentration exceeds the amorphous solubility. These nanodroplets have been shown to be beneficial for …

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How broadly can poly(urethane)-based implants be applied to drugs of varied properties?

Michael B. Lowinger, James D. Ormes, Yongchao Su, James H. Small et autres

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Direct visualization of drug release in injectable implant by laser induced breakdown spectroscopy (LIBS)

Lanfang Zou, Mallory J. Stenslik, Morgan B. Giles, James D. Ormes et autres

A novel laser induced breakdown spectroscopy (LIBS) 2D imaging method is used to directly visualize the drug release process of long-acting injectable (LAI) implants for the first time.

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Designing an ADME liquid formulation with matching exposures to an amorphous dosage form

Hanmi Xi, Zhen Yang, Aditya S. Tatavarti, Wei Xu et autres

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In situ analytical characterization and chemical imaging of tablet coatings using laser induced breakdown spectroscopy (LIBS)

Lanfang Zou, Brittany Kassim, Joseph P. Smith, James D. Ormes et autres

Laser induced breakdown spectroscopy (LIBS) has emerged as an innovative tool for quantitative and qualitative elemental analysis in pharmaceutical research. Herein, the potential use of LIBS for rapid characterization of tablet coatings is illustrated, including the investigation of coating thickness, coating uniformity …

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Impact of Bile Salts on Solution Crystal Growth Rate and Residual Supersaturation of an Active Pharmaceutical Ingredient

Jennifer Qing Lu, James D. Ormes, Michael B. Lowinger, Amanda K. P. Mann et autres

Supersaturating formulations have become a popular approach to address the issue of inadequate aqueous solubility for small molecules. Given that prevention of nucleation may not be always possible, it is of particular interest to control crystal growth from supersaturated solutions in order …

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Insights into Nano- and Micron-Scale Phase Separation in Amorphous Solid Dispersions Using Fluorescence-Based Techniques in Combination with Solid State Nuclear Magnetic Resonance Spectroscopy

Hitesh S. Purohit, James D. Ormes, Sugandha Saboo, Yongchao Su et autres

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