J. Edward Puzas

High‐dose vitamin D to attenuate bone loss in patients with prostate cancer on androgen deprivation therapy: A phase 2 RCT

Luke J. Peppone, Amber S. Kleckner, Chunkit Fung, J. Edward Puzas et autres

BACKGROUND: Androgen deprivation therapy (ADT) inhibits prostate cancer growth. However, ADT causes loss of bone mineral density (BMD) and an increase in fracture risk; effective interventions for ADT-induced bone loss are limited. METHODS: A phase 2 randomized controlled trial investigated the feasibility, …

us (code pays fourni par la source)

Neonatal hyperoxia impairs adipogenesis of bone marrow-derived mesenchymal stem cells and fat accumulation in adult mice

Collynn F. Woeller, Sydney Lim, Elisa Roztocil, Min Yee et autres

us (code pays fourni par la source)

Secondary Fracture Prevention: Consensus Clinical Recommendations From a Multistakeholder Coalition

Robert B. Conley, Gemma Adib, Robert A. Adler, Kristina Åkesson et autres

Osteoporosis-related fractures are undertreated, due in part to misinformation about recommended approaches to patient care and discrepancies among treatment guidelines. To help bridge this gap and improve patient outcomes, the American Society for Bone and Mineral Research assembled a multistakeholder coalition to …

us (code pays fourni par la source)

Correction to Fracture-Targeted Delivery of β‑Catenin Agonists via Peptide-Functionalized Nanoparticles Augments Fracture Healing

Yuchen Wang, Maureen Newman, Marian A. Ackun‐Farmmer, Michael P. Baranello et autres

ADVERTISEMENT RETURN TO ISSUEPREVAdditions and Correc...Additions and CorrectionsNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Fracture-Targeted Delivery of β-Catenin Agonists via Peptide-Functionalized Nanoparticles Augments Fracture HealingYuchen WangYuchen WangMore by Yuchen Wang, Maureen R. NewmanMaureen R. NewmanMore by Maureen R. Newman, Marian Ackun-FarmmerMarian Ackun-FarmmerMore …

Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition

Robert B. Conley, Gemma Adib, Robert A. Adler, Kristina Åkesson et autres

Osteoporosis-related fractures are undertreated, due in part to misinformation about recommended approaches to patient care and discrepancies among treatment guidelines. To help bridge this gap and improve patient outcomes, the American Society for Bone and Mineral Research assembled a multistakeholder coalition to …

us, se, au, gb, sk, gr, ca, it (code pays fourni par la source)

Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition

Robert B. Conley, Gemma Adib, Robert A. Adler, Kristina Åkesson et autres

Osteoporosis-related fractures are undertreated, due in part to misinformation about recommended approaches to patient care and discrepancies among treatment guidelines. To help bridge this gap and improve patient outcomes, the American Society for Bone and Mineral Research assembled a multistakeholder coalition to …

us, sy, se, au, gb, qa, sk, gr, ca, it (code pays fourni par la source)

Metal ion toxicity in the skeleton: lead and aluminum

J. Edward Puzas, Brendan F. Boyce

us (code pays fourni par la source)

List of Contributors

David Abraham, Maria Cecília Puntel de Almeida, Elena Ambrogini, Andrew Arnold et autres

gb, us, hu, be, ca, it (code pays fourni par la source)

Commentary on “Mandible exosomal ssc-mir-133b regulates tooth development in miniature swine via endogenous apoptosis”

J. Edward Puzas

This report, “Mandible exosomal ssc-mir-133b regulates tooth development in miniature swine via endogenous apoptosis” by Li et al. is an important step forward in describing the factors that control tooth development in a large animal model. That many of the regulatory miRNA …

us (code pays fourni par la source)

The effects of high-dose calcitriol and individualized exercise on bone metabolism in breast cancer survivors on hormonal therapy: a phase II feasibility trial

Luke J. Peppone, Marilyn N. Ling, Alissa Huston, Mary E. Reid et autres

us, br (code pays fourni par la source)

Multivalent Presentation of Peptide Targeting Groups Alters Polymer Biodistribution to Target Tissues

Maureen Newman, Steven G. Russell, Christopher S. Schmitt, Ian A. Marozas et autres

Drug delivery to bone is challenging, whereby drug distribution is commonly <1% of injected dose, despite development of several bone-targeted drug delivery systems specific to hydroxyapatite. These bone-targeted drug delivery systems still suffer from poor target cell localization within bone, as at …

us (code pays fourni par la source)

Fracture-Targeted Delivery of β-Catenin Agonists via Peptide-Functionalized Nanoparticles Augments Fracture Healing

Yuchen Wang, Maureen Newman, Marian A. Ackun‐Farmmer, Michael P. Baranello et autres

Despite several decades of progress, bone-specific drug delivery is still a major challenge. Current bone-acting drugs require high-dose systemic administration which decreases therapeutic efficacy and increases off-target tissue effects. Here, a bone-targeted nanoparticle (NP) delivery system for a β-catenin agonist, 3-amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide, a …

us (code pays fourni par la source)