Jorge Cortés

Mucormicosis gastrointestinal en una paciente diabética. Revisión en relación a un caso clínico

Hugo Vilchez, Catalina Pino, Jorge Cortés, Camila Navarro et autres

Resumen La mucormicosis es una infección fúngica invasora poco frecuente y potencialmente letal, causada por hongos del orden Mucorales. La localización gastrointestinal de estas infecciones es infrecuente, representando menos de 15% de todos los casos. Se presenta el caso clínico de una …

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Real world outcomes of patients with CML-CP treated with tyrosine kinase inhibitors from the h. jean khoury cure CML consortium (HJKC3)

Ehab L. Atallah, Emily Giever, Jorge Cortés, Ryan Conrardy et autres

Abstract Background: The H. Jean Khoury Cure CML Consortium (HJKC3) was established with the overarching goals of improving the outcomes for patients (pts) with CML and achieving a deeper understanding of CML biology through innovative clinical trial paired with rationally-designed correlative studies …

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Global gender and geographic disparities in leukemia clinical trials authorship

Kellen Tjioe, Mili Patel, J Liu, Marisol Miranda et autres

Abstract Introduction: Authorship not only reflects scientific contribution but also serves as metrics for academic recognition and career advancement. Although disparities in author gender and geographic distribution have been reported in different types of cancer, limited data exist on the representation of …

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The weight of stress: Allostatic load as a predictor of vaso-occlusive episodes in adults with sickle cell disease

Marisol Miranda, Kellen Tjioe, Siera Gollan, Natasha Alford et autres

Abstract Introduction: Sickle cell disease (SCD) is a debilitating hemoglobinopathy caused by a point mutation in the HBB gene, inducing hemoglobin S polymerization and erythrocyte sickling under hypoxia. Clinical manifestations include recurrent vaso-occlusive episodes (VOEs) leading to severe pain, organ damage, and …

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Dosing variability of tyrosine kinase inhibitors in chronic myeloid leukemia

Joshua Knapp, Kendall Diebold, Devan Parker, Sarah Worth et autres

Abstract Introduction Tyrosine kinase inhibitors (TKIs) have been the standard therapy for chronic myeloid leukemia (CML) since 2001. The current approved doses of these TKIs are largely derived from phase I studies yet the optimal starting and maintenance dose to ensure successful …

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A phase I study of the T-cell receptor-like antibody Hu8F4 in pts with advanced myeloid neoplasms

Tapan Kadia, Caitlin R. Rausch, Gheath Alatrash, Wei‐Ying Jen et autres

Abstract Background: Allogeneic (allo) stem cell transplantation (SCT) has been associated with improvement in long term outcomes in patients with myeloid malignancies. The effectiveness of allo SCT and its associated graft vs. leukemia effect suggests a critical role for immune-based approaches in …

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Imatinib in chronic myeloid leukemia: A comparative assessment of patients in pivotal clinical trials and real-world settings

Marisol Miranda, Josh Wilson, Yazmin Reategui Almonacid, Lily Johnson et autres

Abstract Introduction: Several tyrosine kinase inhibitors (TKIs) are now available for the management of patients with chronic myeloid leukemia (CML). Although clinical trials (CTs) have established the efficacy and safety of TKIs, the generalizability of these findings to broader real-world populations remains …

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Racial/Ethnic and Age-Related Disparities in Early-Onset Colorectal Cancer Diagnoses and Survival

Meng‐Han Tsai, Jorge Cortés, Kenneth J. Vega

Introduction Early-onset colorectal cancer (EOCRC) patients are more likely to have advanced diagnoses across different race/ethnicity or age at diagnosis groups. Thus, we examined the relationship of racial/ethnic disparities with cancer diagnoses (tumor features and histologic types) and 5-year causes-specific survival for …

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Adding categories to EuroQol-5D instrument to remove the ceiling effect

Jorge Cortés, Juan F. Blanco, CLÁUDIO RENATO OLIVEIRA BELTRÃO DE CASTRO, Rosa A. Sepulveda et autres

Las ciencias del mar en la Revista de Biología Tropical en su 50 aniversario

Jorge Cortés

El primer artículo sobre cualquier tema marino fue publicado en 1963 y desde entonces ha venido aumentando el número de publicaciones marinas hasta llegar a 637. Este número representa el 27% de todos los artículos publicados en la RBT (excluyendo los Suplementos) …

Gestión de riesgo para la prescripción de terapias biológicas

Elías Forero, Monique Chalem, Gloria M Vásquez, Edwin A. Jauregui et autres

Risk management for prescribing biological therapies

Elías Forero, Monique Chalem, Gloria M Vásquez, Edwin A. Jauregui et autres