Magdolna Deák

Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk variants

Olivia Castellini-Pérez, Elena Povedano, Guillermo Barturen, Manuel Martínez‐Bueno et autres

The heterogeneity of systemic lupus erythematosus (SLE) can be explained by epigenetic alterations that disrupt transcriptional programs mediating environmental and genetic risk. This study evaluated the epigenetic contribution to SLE heterogeneity considering molecular and serological subtypes, genetics and transcriptional status, followed by …

es, gb, it, fr, be, pt, de, at, ch, hu (code pays fourni par la source)

Interferon and B-cell Signatures Inform Precision Medicine in Lupus Nephritis

Ioannis Parodis, Julius Lindblom, Daniel Toro‐Domínguez, Lorenzo Beretta et autres

Introduction Current therapeutic management of lupus nephritis (LN) fails to induce long-term remission in over 50% of patients, highlighting the urgent need for additional options. Methods We analysed differentially expressed genes in peripheral blood from active LN (n=41) and active non-renal lupus …

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Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

Martin Kerick, Marialbert Acosta‐Herrera, Carmen Pilar Simeón‐Aznar, José Luís Callejas-Rubio et autres

Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk. Imputed total C4, C4A, C4B, and HERV-K CN were analyzed in 26,633 individuals and …

es, us, de, it, nl, se, no, au, fr, be, pt, at (code pays fourni par la source)

Integrative epigenomics in Sjögren´s syndrome reveals novel pathways and a strong interaction between the HLA, autoantibodies and the interferon signature

María Teruel, Guillermo Barturen, Manuel Martínez‐Bueno, Olivia Castellini-Pérez et autres

Primary Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration and damage of exocrine salivary and lacrimal glands. The etiology of SS is complex with environmental triggers and genetic factors involved. By conducting an integrated multi-omics study, we confirmed …

es, ch, de, it, fr, be, pt, br, gb, us, at, hu (code pays fourni par la source)

A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome

Perrine Soret, Christelle Le Dantec, Emiko Desvaux, Nathan Foulquier et autres

There is currently no approved treatment for primary Sjögren's syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies is -in part- because of the heterogeneity in the clinical manifestation and pathophysiology of the disease. Finding common molecular …

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Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases

Guillermo Barturen, Sepideh Babaei, Francesc Català‐Moll, Manuel Martínez‐Bueno et autres

OBJECTIVE: Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes early diagnosis and effective treatment, issues that may be addressed if patients could be classified into groups defined by molecular pattern. This study was undertaken to identify molecular clusters for reclassifying systemic …

es, de, fr, gb, pt, it, se, be, at, ch (code pays fourni par la source)

Standardization procedure for flow cytometry data harmonization in prospective multicenter studies

Lucas Le Lann, P Jouve, Marta E. Alarcón‐Riquelme, Christophe Jamin et autres

One of the most challenging objective for clinical cytometry in prospective multicenter immunomonitoring trials is to compare frequencies, absolute numbers of leukocyte populations and further the mean fluorescence intensities of cell markers, especially when the data are generated from different instruments. Here, …

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IgM antibodies against malondialdehyde and phosphorylcholine in different systemic rheumatic diseases

Divya Thiagarajan, N. Yu. Oparina, Susanna L. Lundström, Roman A. Zubarev et autres

IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) may have protective properties in cardiovascular and rheumatic diseases. We here compare these antibodies in systemic rheumatic conditions and study their properties. Anti-PC and anti-MDA was measured using ELISA in patients with SLE (374), …

se, it, fr, be, pt, es, de, at, ch, hu (code pays fourni par la source)

O31 Integrative analysis reveals a molecular stratification of systemic autoimmune diseases

Guillermo Barturen, Sepideh Babaei, Francesc Català‐Moll, Manuel Martínez‐Bueno et autres

Background Clinical heterogeneity, a hallmark of systemic autoimmune diseases (SADs) impedes early diagnosis and effective treatment, issues that may be addressed if patients could be grouped into a molecular defined stratification. Methods With the aim of reclassifying SADs independently of the clinical …

es, de, fr, gb, pt, it, be, at, ch (code pays fourni par la source)

Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases

Guillermo Barturen, Sepideh Babaei, Francesc Català‐Moll, Manuel Martínez‐Bueno et autres

SUMMARY Background Clinical heterogeneity, a hallmark of systemic autoimmune diseases (SADs) impedes early diagnosis and effective treatment, issues that may be addressed if patients could be grouped into a molecular defined stratification. Methods With the aim of reclassifying SADs independently of the …

es, de, fr, gb, pt, it, be, at, ch (code pays fourni par la source)

Szónokverseny Erdélyben

Magdolna Deák

Investigation of immunological alterations influencing the clinical picture of systemic lupus erythematosus

Magdolna Deák

hu (code pays fourni par la source)