Xinming Xu

Machine learning driven multi-omics analysis of the genetic mechanisms behind the double-coat fleece formation in Hetian sheep

Yanwei Zhang, Wenrong Li, Xinming Xu, Mengxuan Xie et autres

Introduction: The double-coated fleece is crucial for the adaptability and economic value of Hetian sheep, yet its underlying molecular mechanisms remain largely unexplored. Methods: We integrated genome and transcriptome data from double-coated Hetian sheep and single-coated Chinese Merino sheep. Candidate genes associated …

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Investigation of high fecundity genes by nanopore sequencing in sheep (Ovis aries) pituitary

Xue Xiao, Zhibin Ji, Tong Wang, D.M. Zhu et autres

BACKGROUND: Reproduction is a complex process, which is influenced by the inheritance of many minor genes and some major genes. The pituitary gland is an important endocrine organ that regulates estrus and reproduction in sheep mainly through hormone synthesis and secretion. Previous …

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Scanning and Mining of High Fecundity Genes by Oxford Nanopore Technologies (ONT) in Sheep (Ovis aries) Pituitary

Xue Xiao, Lin Ju, Zhibin Ji, Tong Wang et autres

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Sheep IGFBP2 and IGFBP4 promoter methylation regulates gene expression and hair follicle development

Yuezhen Tian, Jianwen Du, Xuemei Yang, Weidan Zeng et autres

Hair follicle development is important for the fineness of wool. Our previous methylated DNA immunoprecipitation sequencing showed that IGFBP2 and IGFBP4 were differentially methylated at different development stages of the hair follicle of Super Merino sheep. This study selected these two genes …

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Effect of the FA2H Gene on cashmere fineness of Jiangnan cashmere goats based on transcriptome sequencing

Cuiling Wu, Jianying Li, Xinming Xu, Qi Xu et autres

BACKGROUND: Cashmere goats are a heterogeneous hairy mammal. The fineness of cashmere can affect its economic value. Therefore, in this study, we used transcriptome sequencing techniques to analyze the gene expression profiles of the skin tissues of cashmere goats with different cashmere …

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The Effect of Integrating Genomic Information into Genetic Evaluations of Chinese Merino Sheep

Wei Chen, Hanpeng Luo, Bingru Zhao, Kechuan Tian et autres

Genomic evaluations are a method for improving the accuracy of breeding value estimation. This study aimed to compare estimates of genetic parameters and the accuracy of breeding values for wool traits in Merino sheep between pedigree-based best linear unbiased prediction (PBLUP) and …

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Identification of SNPs and expression patterns of FZD3 gene and its effect on wool traits in Chinese Merino sheep (Xinjiang Type)

Bingru Zhao, Xuefeng Fu, Kechuan Tian, Xixia Huang et autres

As a member of the Frizzled family, Frizzled3 (FZD3) is a receptor of the canonical Wnt signaling pathway and plays a vital role in mammalian hair follicle developmental processes. However, its effects on wool traits are not clear. The objectives of this …

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Genome-wide identification and characterization of long non-coding RNAs expressed during sheep fetal and postnatal hair follicle development

Ablat Sulayman, Kechuan Tian, Xixia Huang, Yuezhen Tian et autres

Long non-coding RNAs (lncRNAs), >200 nt in length, are transcribed from mammalian genomes. They play important regulatory roles in various biological processes; However, the function and expression profile of lncRNAs involved in the development of hair follicles in the fetus, have been …

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Association analysis of polymorphisms in six keratin genes with wool traits in sheep

Ablat Sulayman, Mahira Tursun, Yiming Sulaiman, Xixia Huang et autres

Objective: The purpose of this study was to investigate the genetic effects of six keratin (KRT) genes on the wool traits of 418 Chinese Merino (Xinjiang type) (CMXT) individuals.Methods: To explore the effects and association of six KRT genes on sheep wool …

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Identification of Polymorphisms and Association of Five KAP Genes with Sheep Wool Traits

Ablat Sulayman, Amat Mamat, Mahira Taursun, Xixia Huang et autres

Ahead of Print article withdrawn by publisher.

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Comparative study of 13 candidate genes applying multi-reference normalization to detect the expression of different fineness in skin tissues of wool sheep

Yuezhen Tian, Xinming Xu

Fiber diameter is a useful indicator of wool traits and it is the main determinant of wool quality and value. A comparative study was conducted to analyze the abundance and expression of 13 candidate genes using expression profile microarray analysis and to …

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Genome Array on Differentially Expressed Genes of Skin Tissue in Cashmere Goat at Early Anagen of Cashmere Growth Cycle Using DNA Microarray

Jiang Di, Xinming Xu, Lazate Ainiwaer, Yanhua Zhang et autres

In order to study the molecular mechanism involved in cashmere regeneration, this study investigated the gene expression profile of skin tissue at various stages of the cashmere growth cycle and screen differentially expressed genes at proangen in 10 cashmere goats at 2 …

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