L. A. Jones

Large scale deployment of rAmpSeq genotyping technology in maize genomic selection

Michael S. Olsen, Kelly R. Robbins, Kate A. Dreher, Claudia P. Ayala et autres

Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of GSK2336805, an Inhibitor of Hepatitis C Virus (HCV) NS5A, in Healthy Subjects and Subjects Chronically Infected with HCV Genotype 1

David A. Wilfret, Jill T. Walker, Kimberly K. Adkison, L. A. Jones et autres

GSK2336805 is an orally bioavailable hepatitis C virus (HCV) inhibitor working through an NS5A-mediated mechanism. This first-time-in-human study was conducted to assess the safety, tolerability, pharmacokinetics, metabolism, and efficacy of GSK2336805 in healthy subjects and subjects infected with HCV genotype 1. We …

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Echocardiogram Study To Evaluate the Effect of the Novel Hepatitis C Virus NS5A Inhibitor GSK2336805 on Cardiac Contractility in Healthy Subjects

David A. Wilfret, Kimberly K. Adkison, L. A. Jones, Yu Lou et autres

GSK2336805 is a hepatitis C virus NS5A inhibitor in clinical development for the treatment of chronic hepatitis C virus infection. This was a single-center, randomized, double-blind, placebo-controlled, two-period crossover study in healthy adults to evaluate the effects of a single 150-mg dose …

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2-Ester Prodrugs of the Varicella-Zoster Antiviral Agent, 6-Methoxypurine Arabinoside

Stanley D. Chamberlain, Allan R. Moorman, L. A. Jones, Paulo de Miranda et autres

6-Methoxypurine arabinoside [9-(β-D-arabinofuranosyl)-6-methoxy-9H-purine; 1] is a potent and selective agent against varicella-zoster virus in vitro. Studies in the rat indicated that extensive first pass metabolism of this nucleoside occurred after oral dosing, presumably from high levels of adenosine deaminase in the intestine. …

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5′Prime;-Ester Prodrugs of the Varicella-Zoster Antiviral Agent, 6-Methoxypurine Arabinoside

Allan R. Moorman, Stanley D. Chamberlain, L. A. Jones, Paulo de Miranda et autres

The potent and selective activity of 6-methoxypurine arabinoside (9-[β-D-arabinofuranosyl]-6-methoxy-9H-purine; 1) and its pharmacokinetic limitations have been described previously. In an attempt to circumvent first-pass catabolism following oral administration, a series of 5′-esters (2a-t) was prepared by dicyclohexyl-carbodiimide-promoted condensation with formic acid in …

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2′- and 5′-ester prodrugs of the varicella-zoster antiviral agent, 6-methoxypurine arabinoside

Allan R. Moorman, Stanley D. Chamberlain, L. A. Jones, Paulo de Miranda et autres

Effects of Halothane on Left Ventricular Relaxation and Early Diastolic Coronary Blood Flow in the Dog

Ramona L. Doyle, Pierre Foëx, William Allen Ryder, L. A. Jones

The effects of graded concentrations of halothane on left ventricular relaxation and phasic coronary blood flow (CBF) were studied in six open-chest, anesthetized dogs. Global and regional left ventricular function were measured. Besides the expected dose-dependent depression of contractility, regional shortening, and …

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Quantitation of fecal carbohydrate excretion in patients with short bowel syndrome

Vanessa Z. Ameen, Geraldine Keating Powell, L. A. Jones

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A new syndrome of bile acid deficiency—a possible synthetic defect

Geraldine Keating Powell, L. A. Jones, Joan Richardson

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