M. Fujisawa

THE GENETIC SUBTYPES AND THE TUMOR MICROENVIRONMENT SIGNATURES ARE ASSOCIATED WITH DISTINCT OUTCOMES IN PERIPHERAL T‐CELL LYMPHOMA

Yasuhito Suehara, Kana Sakamoto, M. Fujisawa, Kota Fukumoto et autres

Background: Emerging evidence suggests the prognostic impact of the tumor microenvironment (TME) in peripheral T-cell lymphomas (PTCLs). To better understand PTCL pathobiology, we performed an integrative multi-omics study to explore the genetic subtypes and the TME signatures of PTCLs, especially nodal T-follicular …

jp, us (code pays fourni par la source)

Low-birth-weight infant with Antley-Bixler syndrome-like phenotype caused by POR mutation: a rare case report.

George Imataka, M. Fujisawa, Ryosei KURIBAYASHI, Go Ichikawa et autres

jp (code pays fourni par la source)

Risk factors of kidney anatomy for difficult access to lower pole

S Imai, T. Inoue, S. Nakayama, Heuvel Lambertus van den et autres

PS1308 TARGETING T‐CELL RECEPTOR SIGNALING PATHWAY BY DASATINIB IN RELAPSED/REFRACTORY ANGIOIMMUNOBLASTIC T‐CELL LYMPHOMA

Yusuke Kiyoki, Mamiko Sakata‐Yanagimoto, Tamia Nguyen, M. Fujisawa et autres

Background: Angioimmunoblastic T‐cell lymphoma (AITL) is an intractable T‐cell lymphoma. The recurrent hotspot (p.Gly17Val) mutations in RHOAencoding a small GTPase, together with the loss‐of‐function mutations in TET2encoding an epigenetic regulator, are the genetic hallmark in AITL. We previously identified that the p. …

us, jp, in, gb (code pays fourni par la source)

Directed differentiation of feeder-free human induced pluripotent stem cells into stratified bladder urothelium

Kotaro Suzuki, Michiyo Koyanagi‐Aoi, Keiichiro Uehara, Nobuyuki Hinata et autres

Activation of RHOA–VAV1 signaling in angioimmunoblastic T-cell lymphoma

M. Fujisawa, Mamiko Sakata‐Yanagimoto, Shoko Nishizawa, Daisuke Komori et autres

Somatic G17V RHOA mutations were found in 50-70% of angioimmunoblastic T-cell lymphoma (AITL). The mutant RHOA lacks GTP binding capacity, suggesting defects in the classical RHOA signaling. Here, we discovered the novel function of the G17V RHOA: VAV1 was identified as a …

jp, us, fr (code pays fourni par la source)

ACTIVATION OF RHOA‐VAV1 SIGNALING IN ANGIOIMMUNOBLASTIC T‐CELL LYMPHOMA

Mamiko Sakata‐Yanagimoto, M. Fujisawa, Shoko Nishizawa, Daisuke Komori et autres

Introduction: Somatic RHOA mutations encoding a p.Gly17Val alteration (G17 V RHOA mutation) occur in 70% of angioimmunoblastic T-cell lymphoma (AITL). RHOA, a small GTPase is converted from the GDP-bound inactive form to the active GTP-bound form by guanine nucleotide exchange factors (GEFs). …

jp, us, fr (code pays fourni par la source)

The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells

Yuichiro Nishida, Aya Maeda, M J Kim, Long Cao et autres

Abstract Disease recurrence is the major problem in the treatment of acute myeloid leukemia (AML). Relapse is driven by leukemia stem cells, a chemoresistant subpopulation capable of re-establishing disease. Patients with p53 mutant AML are at an extremely high risk of relapse. …

jp, us (code pays fourni par la source)

Clinical significance of circulating plasma cells in myeloma; 6-color multiparameter flowcytometry analysis

M. Fujisawa, Yasuhito Suehara, Kota Fukumoto, Yoshiaki Usui et autres

jp (code pays fourni par la source)

Heavy/Light Chain Analysis for Response Monitoring in Multiple Myeloma Patients: Comparisons With Immunofixation, Serum Free Light Chain, and Multicolor Flow-Cytometry Analysis

Kosei Matsue, Yasuhito Suehara, Kota Fukumoto, M. Fujisawa et autres

jp (code pays fourni par la source)

Rapid reduction in iFLC predicts achievement of VGPR after 4 cycles of VCD treatment: Shimousa MM-01 VCD study

Masao Takeuchi, Atsuko K. Yamazaki, Koki Akao, Yusuke Isshiki et autres

jp (code pays fourni par la source)

2605 Early tumor shrinkage under treatment with first-line tyrosine kinase inhibitors as a surrogate endpoint of overall survival in patients with metastatic renal cell carcinoma

Hideaki Miyake, Hiroyuki Momozono, M. Fujisawa