Martin K. O’Donohoe

Macrophage DNases Limit Neutrophil Extracellular Trap–Mediated Defective Efferocytosis in Atherosclerosis

Umesh Kumar Dhawan, Tanwi Vartak, Hanna Englert, Stefan Russo et autres

BACKGROUND: Neutrophil extracellular traps (NETs) contribute to atherosclerosis progression and are linked to adverse clinical outcomes such as myocardial infarction and stroke. Although the triggers of NET formation in plaques are known, the mechanisms governing DNase-mediated NET clearance and how these are …

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Computed tomography analysis of vulnerable carotid atherosclerotic plaque and relationship to clinical characteristics

Nicola Giannotti, Jonathan P McNulty, Shane J. Foley, Mary Claire Barry et autres

Abstract Objective The presence of atherosclerotic plaque components such as lipid rich necrotic core and intraplaque haemorrhage is associated with increased plaque vulnerability, and may be used to stratify the risk of future cerebrovascular events. Our aim was to investigate the relationship …

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Eversion Endarterectomy – An Alternative Approach to Occlusive External Iliac Artery disease

Megan Power Foley, Thomas Michael Aherne, Conor Dooley, Edward Mulkern et autres

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Association Between 18-FDG Positron Emission Tomography and MRI Biomarkers of Plaque Vulnerability in Patients With Symptomatic Carotid Stenosis

Nicola Giannotti, Jonathan P McNulty, Shane J. Foley, John Joseph McCabe et autres

Purpose: Pathologic studies suggest that unstable plaque morphology and inflammation are associated with cerebrovascular events. 18F-fluorodeoxyglucose positron emission tomography (18FDG-PET) is a validated technique for non-invasive imaging of inflammation-related plaque metabolism, and MRI can identify morphologic features of plaque instability. The aim …

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AB041. SOH21AS123. Impact of COVID-19 on patients undergoing carotid endarterectomy for symptomatic disease

Lauren Leddy, Aisling Kelly, Cleona Gray, Edward Mulkern et autres

Background: The risk of disabling stroke is highest in the first 14 days after onset of symptoms. Current European Society of Vascular Surgery guidelines recommend that carotid endarterectomy should be performed within 14 days of symptom onset in patients with the appropriate …

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Reducing the risk of venous thromboembolism following superficial endovenous treatment: A UK and Republic of Ireland consensus study

Nikesh Dattani, Joseph Shalhoub, Sandip Nandhra, Tristan R.A. Lane et autres

OBJECTIVES: Venous thromboembolism is a potentially fatal complication of superficial endovenous treatment. Proper risk assessment and thromboprophylaxis could mitigate this hazard; however, there are currently no evidence-based or consensus guidelines. This study surveyed UK and Republic of Ireland vascular consultants to determine …

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AB034. TIA to CEA: time from symptoms to surgery for carotid endarterectomy at a tertiary referral centre

Megan Power Foley, Cleona Gray, Edward Mulkern, Ciarán Osmond McDonnell et autres

Background: Stroke is the leading cause of disability and second leading cause of death globally. Carotid artery stenosis accounts for 10-15% of ischaemic strokes. Carotid endarterectomy (CEA) is a surgical method of stroke risk reduction in patients with high-grade stenosis. Best evidence …

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Carotid Plaque Inflammation Imaged by 18 F-Fluorodeoxyglucose Positron Emission Tomography and Risk of Early Recurrent Stroke

Peter J. Kelly, Pol Camps‐Renom, Nicola Giannotti, Joan Martí‐Fábregas et autres

Background and Purpose— Plaque inflammation contributes to stroke and coronary events. 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) identifies plaque inflammation-related metabolism. Almost no prospective data exist on the relationship of carotid 18 F-FDG uptake and early recurrent stroke. Methods— We did …

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The use of high venous ligation as an adjunct to endovenous therapy in the management of great saphenous vein incompetence: A systematic review and meta-analysis of randomized controlled trials

Thomas Michael Aherne, Mekki Medani, Shaheel Mohammad Sahebally, Elrasheid A. H. Kheirelseid et autres

Background In recent years, endovenous intervention has emerged as a minimally invasive alternative to open venous surgery. However, endovenous intervention does not formally disconnect the deep and superficial venous systems and it is hypothesized that recurrence may be greater in the absence …

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AB033. 153. Want not, waste not: excessive preoperative crossmatch requests for vascular peripheral bypass surgery

Megan Power Foley, Imelda Keane, Michael Fay, Ciarán Osmond McDonnell et autres

Background: Blood products are essential for safe surgery, however, the over-ordering of blood for elective procedures wastes hospital resources. A Maximum Surgical Blood Ordering Schedule (MSBOS) guides preoperative orders, improving efficiency and reducing costs. As surgical techniques change, so can the need …

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AB030. 219. Eversion endarterectomy in iliac occlusive artery disease

Megan Power Foley, Thomas Michael Aherne, Conor Dooley, Martin K. O’Donohoe et autres

Background: Iliac eversion endarterectomy (IEE) offers an underutilised alternative to endovascular or prosthetic reconstruction in iliac occlusive disease. Methods: All IEEs performed in a university hospital vascular centre over 17 years (from 2000 to 2017) were reviewed. Demographic, risk factors, operative and …

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Color Duplex Ultrasound as Suitable Alternative for CTA in Post EVAR Surveillance

Conor Dooley, Mekki Medani, Méabh O’Hare, Thomas Michael Aherne et autres

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