Thiago Braido Dias

Prasugrel or ticagrelor monotherapy vs dual antiplatelet treatment after percutaneous coronary intervention in acute coronary syndromes: a landmark analysis from the NEO-MINDSET trial

Caio de Assis Moura Tavares, Patrícia O. Guimarães, Marcelo Franken, Karla Santo et autres

BACKGROUND AND AIMS: The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention in patients with acute coronary syndrome remains uncertain. This analysis examined the temporal patterns of ischaemic and bleeding risks of early aspirin withdrawal compared with DAPT. METHODS: …

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Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity

Anna Lima, Daniel Rodrigues, Mirele R. Machado, José Teles Oliveira-Neto et autres

Perivascular adipose tissue (PVAT) negatively regulates vascular muscle contraction. However, in the context of obesity, the PVAT releases vasoconstrictor substances that detrimentally affect vascular function. A pivotal player in this scenario is the peptide endothelin-1 (ET-1), which induces oxidative stress and disrupts …

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Modificação de proteínas por O-GlcNAc em artérias humanas: alterações na hipertensão arterial

Thiago Braido Dias

Em conclusão, a VBH

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Increased O-GlcNAcylation of Endothelial Nitric Oxide Synthase Compromises the Anti-contractile Properties of Perivascular Adipose Tissue in Metabolic Syndrome

Rafael M. Costa, Josiane F. Silva, Juliano Alves, Thiago Braido Dias et autres

Under physiological conditions, the perivascular adipose tissue (PVAT) negatively modulates vascular contractility. This property is lost in experimental and human obesity and in the metabolic syndrome, indicating that changes in PVAT function may contribute to vascular dysfunction associated with increased body weight …

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O-GlcNAc modification of proteins in human arteries: changes in arterial hypertension

Thiago Braido Dias

Vários mecanismos controlam os processos de contração e relaxamento das células musculares lisas vasculares (CMLVs). Receptores e moléculas sinalizadoras intracelulares, os quais controlam os processos de contração e relaxamento das CMLVs, são alvo de modificações pós-traducionais, como a O-GlcNAcilação que modula respostas …

Stress-induced O-GlcNAcylation: an adaptive process of injured cells

Marissa Martinez, Thiago Braido Dias, Peter Natov, Natasha E. Zachara

In the 30 years, since the discovery of nucleocytoplasmic glycosylation, O-GlcNAc has been implicated in regulating cellular processes as diverse as protein folding, localization, degradation, activity, post-translational modifications, and interactions. The cell co-ordinates these molecular events, on thousands of cellular proteins, in …

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