Takako Okamoto

Data from FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function

Takako Okamoto, Syn Kok Yeo, Mingang Hao, Mary Rose Copley et autres

Abstract Immune checkpoint inhibitors (ICI) have the potential to induce durable therapeutic responses, yet response rates in breast cancer are modest and limited to particular subtypes. To expand the applicability of ICI, we examined the role of an essential autophagy gene, FIP200, …

Data from FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function

Takako Okamoto, Syn Kok Yeo, Mingang Hao, Mary Rose Copley et autres

Abstract Immune checkpoint inhibitors (ICI) have the potential to induce durable therapeutic responses, yet response rates in breast cancer are modest and limited to particular subtypes. To expand the applicability of ICI, we examined the role of an essential autophagy gene, FIP200, …

FiguresS1-S8 from FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function

Takako Okamoto, Syn Kok Yeo, Mingang Hao, Mary Rose Copley et autres

Figures S1 to S8

FiguresS1-S8 from FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function

Takako Okamoto, Syn Kok Yeo, Mingang Hao, Mary Rose Copley et autres

Figures S1 to S8

Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer

Syn Kok Yeo, Xiaoting Zhu, Takako Okamoto, Mingang Hao et autres

Breast cancer stem cells (BCSCs) contribute to intra-tumoral heterogeneity and therapeutic resistance. However, the binary concept of universal BCSCs co-existing with bulk tumor cells is over-simplified. Through single-cell RNA-sequencing, we found that Neu, PyMT and BRCA1-null mammary tumors each corresponded to a …

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Author response: Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer

Syn Kok Yeo, Xiaoting Zhu, Takako Okamoto, Mingang Hao et autres

The unraveling of distinct mammary tumor hierarchies in various mouse models of breast cancer emphasizes the need to account for specific cell states with potentially varying therapeutic vulnerabilities in tumors.

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FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function

Takako Okamoto, Syn Kok Yeo, Mingang Hao, Mary Rose Copley et autres

Immune checkpoint inhibitors (ICI) have the potential to induce durable therapeutic responses, yet response rates in breast cancer are modest and limited to particular subtypes. To expand the applicability of ICI, we examined the role of an essential autophagy gene, FIP200, which …

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Use of dermal fat grafts for treating anetoderma with lipoatrophy following involution of hemangiomas

Tadashi Nomura, Mika Nakasone, Takako Okamoto, Hirotaka Ejiri et autres

Infantile hemangioma (IH) is a benign vascular tumor that gradually involutes over several years. Rapidly involuting congenital hemangioma (RICH) is the relatively rare congenital vascular tumor that is fully grown at birth and does not undergo postnatal growth and involutes during the …

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A Case of Large Sarcoid Choroidal Granuloma Treated with Steroid Pulse Therapy

Takatoshi Kobayashi, Nanae Takai, Takaki Sato, Rei Tada et autres

PURPOSE: To report a case of large sarcoid choroidal granuloma that was successfully treated with steroid pulse therapy. CASE REPORT: A 38-year-old man presented with the primary complaint of decreased visual acuity (VA) in his left eye. Upon examination, a large white …

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[A Surgically Resected Case of Lung Metastases and Sister Mary Joseph's Nodule 24 Months after Operation for Pancreatic Cancer].

Yuka Kono, Tatsuro Oishi, Yuki Ueda, Eiji Matsuoka et autres

Metastatic umbilical tumors from internal malignancy, known as Sister Mary Joseph's Nodule(SMJN), are a relatively rare prognostic sign. An 86-year-old woman with pancreatic body carcinoma underwent distal pancreatectomy for D2 lymph node removal in 20XX. No peritoneal dissemination was found at that …

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Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells

Chenran Wang, Michael A. Haas, Fuchun Yang, Syn Kok Yeo et autres

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Single-Cell Transcriptomic Analysis of Mammary Tumors Reveals Distinct Patterns of Hierarchical and Subtype Heterogeneity

Syn Kok Yeo, Xiaoting Zhu, Takako Okamoto, Mingang Hao et autres

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