S L Harikumar

In Vitro Anti-Inflammatory Evaluation of Sesbania Procumbens Extracts

V. Leslie, Gurfateh Singh, Sijenunu Aron, S L Harikumar

Plants used in the traditional healing system require a systematic evaluation that may give more promising data about their medicinal value and may be useful to meet the rising demand for novel agents to combat infections and diseases. The plant Sesbania procumbens …

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Pharmacokinetic investigation of nitrendipine encapsulated niosomal gel in rat plasma by RP-HPLC method

Abhishek Sharma, Rajiv Sharma, Kundan Singh Bora, S L Harikumar

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Herbicide Glyphosate: Toxicity and Microbial Degradation

Simranjeet Singh, Vijay Kumar, Jatinder Pal Kaur Gill, Shivika Datta et autres

Glyphosate is a non-specific organophosphate pesticide, which finds widespread application in shielding crops against the weeds. Its high solubility in hydrophilic solvents, especially water and high mobility allows the rapid leaching of the glyphosate into the soil leading to contamination of groundwater …

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Quetiapine Fumarate Loaded Nanostructured Lipid Carrier for Enhancing Oral Bioavailability: Design, Development and Pharmacokinetic Assessment

Shweta Agarwal, S L Harikumar, Poonam Negi, Navneet Kumar Upadhyay et autres

AIMS: The study aimed at developing and characterizing Nanostructured Lipid Carriers (NLC) of Quetiapine Fumarate (QF) by Design of Experiment (DoE) for the enhancement of bioavailability. BACKGROUND: QF, an anti-psychotic drug, has an oral bioavailability of 9% due to hepatic first- pass …

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QUALITY BY DESIGN APPROACH FOR DEVELOPMENT AND OPTIMIZATION OF NITRENDIPINE LOADED NIOSOMAL GEL FOR ACCENTUATED TRANSDERMAL DELIVERY

Abhishek Sharma, S L Harikumar

Objective: The purpose of the present investigation was to develop and optimize nitrendipine loaded niosomal gel for transdermal delivery using quality by design approach. Methods: Niosomal formulations were developed by application of the thin-film hydration method using different ratios of span 60, …

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Current trends and epidemiology on novel covid-19: Pandemic

Manoj Kumar Katual, Gurfateh Singh, S L Harikumar

Current trends and epidemiology on novel covid-19: Pandemic - JETHS- Print ISSN No: - 2454-4396 Online ISSN No:- 2393-8005 Article DOI No:- 10.18231/j.jeths.2020.002, Journal of Education Technology in Health Sciences-J Educ Technol Health Sci

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Solubility enhancement of poorly aqueous soluble novel drug using natural gum as carriers

Manoj Kumar Katual, Gurfateh Singh, S L Harikumar

The current article is based on the concept to enhance the solubility and dissolution rate of a model drug, Rosuvastatin Calcium, which is BCS class-II drug with anti-hyperlipidemic potential. The reported bioavailability from oral route of drug is only 20%. So aim …

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Recent advancements in ropinirole hydrochloride embedded nano-techniques in Parkinson’s treatment

Manoj Kumar Katual, Gurfateh Singh, S L Harikumar

Parkinson's Disease (PD) is effecting 7-10 million people of worldwide as the report of WHO 2014. It has proved to be 2nd most a neuro-degenerative disorder of the central nervous system (CNS). It occurs due to the death of dopamine-generating cells in …

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Development and optimization of nanoemulsion based gel for enhanced transdermal delivery of nitrendipine using box-behnken statistical design

Abhishek Sharma, Anupama Singh, S L Harikumar

Objective: The purpose of present research was to develop and statistically optimize nitrendipine nanoemulsion gel for transdermal delivery using box-behnken statistical design.Method: The nanoemulsion formulations bearing nitrendipine were prepared by application of ternary phase diagram and spontaneous emulsification method. Box-behnken design was …

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FORMULATION AND EVALUATION OF LYCOPENE LOADED COLLOIDAL MICROPARTICLES GEL

Monisha Bansal, Manpreet Kaur Walia, Gurfateh Singh, S L Harikumar

Objective: The objective of the present investigation was to design and evaluate a gel containing lycopene loaded colloidal microparticles. Methods: The lycopene loaded colloidal microparticles were successfully prepared by Cloud point technique to form colloids using Tween 40 and Tween 60 surfactant …

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Quality by Design Approach for Development and Characterisation of Solid Lipid Nanoparticles of Quetiapine Fumarate

Shweta Agarwal, R. S. R. Murthy, S L Harikumar, Rajeev Garg

BACKGROUND: Quetiapine fumarate, a 2nd generation anti-psychotic drug has oral bioavailability of 9% because of hepatic first pass metabolism. Reports suggest that co-administration of drugs with lipids affects their absorption pathways, enhances lymphatic transport thus bypassing hepatic first-pass metabolism resulting in enhanced …

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Pharmacokinetic enhancement of poorly aqueous soluble rosuvastatin using natural gum as carriers: pharmaceutical modeling of release kinetics and bio-stastistical evaluation

Manoj Kumar Katual, Gurfateh Singh, S L Harikumar

Pharmacokinetic enhancement of poorly aqueous soluble rosuvastatin using natural gum as carriers: pharmaceutical modeling of release kinetics and bio-stastistical evaluation - IJPCA- Print ISSN No: - 2394-2789 Online ISSN No:- 2394-2797 Article DOI No:- 10.18231/j.ijpca.2019.004, International Journal of Pharmaceutical