Andreia H. Lee

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach, Denzil Bernard, Kong T. Nguyen, Gregory Ho et autres

As a result, the correct Affiliation for Andrew B. Herr, Benjamin Liou, David A. Hildeman, Joseph J. Maciag, Ying Sun, Durga Krishnamurthy, and Stephen N. Waggoner is:

us, br, sg, au, ca, nl, ch, be, it, gb, es (code pays fourni par la source)

AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach, Denzil Bernard, Kong T. Nguyen, Gregory Ho et autres

High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy …

us, br, sg, au, ca, nl, ch, be, it, gb, es (code pays fourni par la source)

Regulation of Proviral Expression and Post-Translational Modifications in Embryonic Cells

Andreia H. Lee

Moloney Murine Leukemia Virus (M-MLV) proviral DNA is transcriptionally silenced in mouse embryonic cells by a repressor complex containing tripartite-motif-containing 28 (Trim28). Trim28 depends on post-translational modifications, such as sumoylation and phosphorylation, and its interactions with several co-repressor proteins to regulate its …

Proviral Silencing in Embryonic Cells Is Regulated by Yin Yang 1

S. P. Schlesinger, Andreia H. Lee, Gary Z. Wang, Lisa Green et autres

Embryonic cells transcriptionally repress the expression of endogenous and exogenous retroelements. Trim28, a key player in this silencing, is known to act in a large DNA-bound complex, but the other components of the complex are not fully characterized. Here, we show that …

us (code pays fourni par la source)