Karen E. Mark

An overview of Instructional approaches and decision-making strategies to curtail curricular overload

Aleda M.H. Chen, Stacy D. Brown, Karen E. Mark, Sarah McBane

OBJECTIVES: Curriculum overload often occurs when content is kept in the curriculum that may no longer be necessary to prepare students for professional practice. The overload becomes compounded by the addition of new content from the ever-changing professional practice needs and updates …

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PD48 Does Unmet Need Influence The Scottish Medicines Consortium Health Technology Assessment Decisions For Rare Disease Conditions?

Karen E. Mark, Vishnu Priya Wahal

Introduction The Scottish Medicines Consortium (SMC) defines end-of-life medicines as drugs used for treating conditions that usually lead to death within three years using currently available treatments. Orphan medicines are drugs used for the treatment of very rare conditions and ultra-orphan drugs …

Occupational HIV Transmission Among Male Adult Film Performers — Multiple States, 2014

Jason A. Wilken, Christopher Ried, Pristeen Rickett, Janet N. Arno et autres

In 2014, the California Department of Public Health was notified by a local health department of a diagnosis of acute human immunodeficiency virus (HIV) infection* and rectal gonorrhea in a male adult film industry performer, aged 25 years (patient A). Patient A …

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Occupational HIV Transmission Among Male Adult Film Performers — Multiple States, 2014

Jason A. Wilken, Christopher Ried, Pristeen Rickett, Janet N. Arno et autres

In 2014, the California Department of Public Health was notified by a local health department of a diagnosis of acute human immunodeficiency virus (HIV) infection* and rectal gonorrhea in a male adult film industry performer, aged 25 years (patient A). Patient A …

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Three Phase III Randomized Controlled Trials of Topical Resiquimod 0.01-Percent Gel To Reduce Anogenital Herpes Recurrences

Karen E. Mark, Spotswood L. Spruance, G R Kinghorn, Stephen L. Sacks et autres

Resiquimod, a Toll-like receptor 7 and 8 agonist, stimulates production of cytokines that promote an antigen-specific T helper type 1 acquired immune response. Animal and phase II human trials showed posttreatment efficacy in reducing recurrent herpes lesion days and/or time to first …

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Herpes Simplex Virus: Rapidly Cleared Reactivation Episodes, Treatment with Topical Resiquimod, and Incidence and Clinical Management of Newly Diagnosed Symptomatic Disease

Karen E. Mark

Thesis (Ph.D.)--University of Washington, 2013

Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract

Joshua T. Schiffer, David A. Swan, Ramzi Al Sallaq, Amalia Magaret et autres

Herpes simplex virus-2 (HSV-2) is shed episodically, leading to occasional genital ulcers and efficient transmission. The biology explaining highly variable shedding patterns, in an infected person over time, is poorly understood. We sampled the genital tract for HSV DNA at several time …

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Estimated HIV Incidence in California, 2006–2009

Susan Scheer, Shoshanna Nakelsky, Trista Bingham, Mark Damesyn et autres

INTRODUCTION: Accurate estimates of HIV incidence are crucial for prioritizing, targeting, and evaluating HIV prevention efforts. Using the methodology the CDC used to estimate national HIV incidence, we estimated HIV incidence in Los Angeles County (LAC), San Francisco (SF), and California's remaining …

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Author response: Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract

Joshua T. Schiffer, David A. Swan, Ramzi Al Sallaq, Amalia Magaret et autres

A combination of detailed sampling and mathematical modeling suggests that the response of immune cells to reactivation of herpes simplex virus 2 is extremely rapid and effective within microscopic areas of genital skin.

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Regional Differences Among HIV Patients in Care: California Medical Monitoring Project Sites, 2007-2008

Susan Scheer, Alison J. Hughes, Judith S. Tejero, Mark Damesyn et autres

INTRODUCTION: The Medical Monitoring Project (MMP) is a national, multi-site population-based supplemental HIV/AIDS surveillance project of persons receiving HIV/AIDS care. We compared California MMP data by region. Demographic characteristics, medical care experiences, HIV treatment, clinical care outcomes, and need for support services …

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Peripheral Blood CD4 T-Cell and Plasmacytoid Dendritic Cell (pDC) Reactivity to Herpes Simplex Virus 2 and pDC Number Do Not Correlate with the Clinical or Virologic Severity of Recurrent Genital Herpes

Nicholas J. Moss, Amalia Magaret, Kerry J. Laing, Angela Shaulov Kask et autres

Leukocytes participate in the immune control of herpes simplex virus (HSV). Data from HIV coinfections, germ line mutations, and case reports suggest involvement of CD4 T cells and plasmacytoid dendritic cells (pDC). We investigated the relationships between these cells and recurrent genital …

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Impact of Herpes Simplex Virus Type 2 on HIV-1 Acquisition and Progression in an HIV Vaccine Trial (the Step Study)

Ruanne V. Barnabas, Judith N. Wasserheit, Yunda Huang, Holly Janes et autres

INTRODUCTION: Extensive observational data suggest that herpes simplex virus type 2 (HSV-2) infection may facilitate HIV acquisition, increase HIV viral load, and accelerate HIV progression and onward transmission. To explore these relationships, we examined the impact of preexisting HSV-2 infection in an …

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