Jeffery R. Fineman

A Large Animal Model of Heritable Pulmonary Arterial Hypertension Using Gene-edited BMPR2 Sheep

Sanjeev A. Datar, Nicholas Werry, Austin R Brown, Devon S. Fitzpatrick et autres

Abstract Pulmonary Arterial Hypertension (PAH) is a rare vascular disorder characterized by elevated pressure in pulmonary arteries, eventually leading to right ventricular failure. Approximately 50% of pediatric disease and 20% of adult disease can be linked to a genetic mutation, with nearly …

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Ventilator-induced Lung Injury Associated With Endothelial Cell Mitochondrial Fission

Marissa D. Pokharel, Georgios D. Kitsios, Panfeng Fu, Alejandro Garcia Flores et autres

Abstract RATIONALE: Mechanical ventilation (MV) represents a cornerstone of supportive care for sepsis-induced acute respiratory distress syndrome. Unfortunately, cyclic positive pressure from MV can exacerbate lung injury, a phenomenon known as ventilator-induced lung injury (VILI). Recent studies highlight the crucial role of …

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C-Terminus of Heat Shock Protein 70–Interacting Protein–Dependent GTP Cyclohydrolase I Degradation in Lambs with Increased Pulmonary Blood Flow

John Hess, Sebastian Haag, Imran Rehmani, Jeffery R. Fineman et autres

We showed that nitric oxide (NO) signaling is decreased in the pulmonary vasculature before the development of endothelial dysfunction in a lamb model of congenital heart disease and increased pulmonary blood flow (Shunt). The elucidation of the molecular mechanism by which this …

Risk Assessment and Monitoring of Chronic Pulmonary Hypertension in Premature Infants

Philip Thaler Levy, Amish Jain, Hythem M. Nawaytou, David Frank Teitel et autres

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miR-486 is modulated by stretch and increases ventricular growth

Stephan C. Lange, Indroneal Banerjee, Katrina Carrion, Ricardo Serrano et autres

Perturbations in biomechanical stimuli during cardiac development contribute to congenital cardiac defects such as hypoplastic left heart syndrome (HLHS). This study sought to identify stretch-responsive pathways involved in cardiac development. miRNA-Seq identified miR-486 as being increased in cardiomyocytes exposed to cyclic stretch …

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oxide: role of cyclic AMP GTP cyclohydrolase I expression is regulated by nitric

Jeffery R. Fineman, Stephen M. Black, Sanjiv Kumar, Xutong Sun et autres

Abstract 511: Ephrin-B2 Is Essential for Ischemic Recovery following Femoral Artery Occlusion in Mice

Rong A. Wang, Yuankai Lin, Weiya Jiang, Ji-Youn Youn et autres

The cell surface protein ephrin-B2 is expressed in arterial and not venous endothelial cells in adulthood mice. The role for ephrin-B2 in adult vascular physiology is currently unknown. We have recently reported that endothelial ephrin-B2 is essential in acute arterial vasodilation. Here …

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Fetus Control Shunt

Zahra Ghorishi, Jay M. Milstein, Francis R. Poulain, Anita J. Moon‐Grady et autres

Elevated tricuspid regurgitant jet velocity in subgroups of thalassemia patients: insight into pathophysiology and the effect of splenectomy

Sylvia T. Singer, Frans A. Kuypers, Jeffery R. Fineman, Ginny L Gildengorin et autres

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C-Terminus of Heat Shock Protein 70–Interacting Protein–Dependent GTP Cyclohydrolase I Degradation in Lambs with Increased Pulmonary Blood Flow

Xutong Sun, Sohrab Fratz, Shruti Sharma, Yali Hou et autres

We showed that nitric oxide (NO) signaling is decreased in the pulmonary vasculature before the development of endothelial dysfunction in a lamb model of congenital heart disease and increased pulmonary blood flow (Shunt). The elucidation of the molecular mechanism by which this …

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Mechanisms of nitric oxide synthase uncoupling in endotoxin-induced acute lung injury: Role of asymmetric dimethylarginine

Shruti Sharma, Anita Smith, Sanjiv Kumar, Saurabh Aggarwal et autres

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A CAUSAL DESIGN TRAJECTORY LINKS DIVERSE FORMS OF PULMONARY HYPERTENSION: EVIDENCE OF A FETAL PHENOTYPE OF ARTERIAL REMODELING UNDER THE PRINCIPLE OF MINIMUM WORK

Roblee P. Allen, Gary W. Raff, Sanjeev A. Datar, Anita J. Moon et autres

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