Rendrik F. Franco

Mapping Methodological Heterogeneity in Biochemical Assays of Non-Covalent DprE1 Inhibitors: A Systematic Review

Rafael Bello Gonçalves, Rendrik F. Franco, Sofia Kühl Fonseca, S. SUEYOSHI et autres

Decaprenylphosphoryl-β-D-ribose 2′-epimerase (DprE1) is an essential enzyme involved in mycobacterial cell-wall biosynthesis and a validated target for antituberculosis drug discovery. However, substantial variation in biochemical assay conditions may limit the comparability and interpretation of reported inhibitory activities. This systematic review aims to …

Pharmacological Applications of Electrospun Nanofibers Loaded with Bioactive Natural Compounds and Extracts: A Systematic Review

Rendrik F. Franco, Paula C. Jimenez

Background/Objectives: This systematic review explores the utilization of electrospinning for the incorporation of natural compounds, focusing on their pharmacological applications. Methods: This systematic review focused on studies investigating the incorporation of natural bioactive compounds into nanofibers produced via the electrospinning technique for …

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Inherited predisposition to malignant mesothelioma: germline BAP1 mutations and beyond.

Francesca Pagliuca, Federica Zito Marino, F Morgillo, Claudia Della Corte et autres

Malignant mesothelioma (MM) is a rare aggressive neoplasm arising from mesothelial lining of body cavities, most commonly pleura and peritoneum. It is characterised by a poor prognosis and limited treatment options. A universally recognised risk factor for the development of MM is …

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37th International Symposium on Intensive Care and Emergency Medicine (part 1 of 3)

V. Karavana, Iain M Smith, G. Kanellis, Ioanna Sigala et autres

Introduction: Aberrant inflammation is a hallmark of acute respiratory distress syndrome (ARDS) pathophysiology.JAK/ STAT3 pathway is critical for macrophages and neutrophils activation and persistent inflammation.This study aims to investigate the therapeutic potential of inhibiting JAK1/3 activity using the small-molecule R548 inhibitor in …

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Innovation in Services: The Case of Fleury—A Diagnostic Medical Center

Eduardo Pinheiro Gondim de Vasconcellos, Liliana Vasconcellos, Rendrik F. Franco, Patricia Yumi Maeda et autres

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RYR1 gene variability and effect on meat pH in Argentinean hybrids swines

Soraya Marini, Leonardo S. Vanzetti, Valeria Soledad Borelli, Angela Villareal et autres

"The RYR1 gene is the principal cause of the porcine stress syndrome (PSS) and the presence of pale, soft and exudative meat (PSE) in swine. In Argentina there are no reports about the variability of RYR1 gene in hybrid swine and its …

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Effect of single nucleotide polymorphisms on expression of the gene encoding thrombin-activatable fibrinolysis inhibitor: a functional analysis

Michael B. Boffa, Deborah Maret, Jeffrey D. Hamill, Nazareth Bastajian et autres

Thrombin-activable fibrinolysis inhibitor (TAFI) is a plasma zymogen that acts as a molecular link between coagulation and fibrinolysis. Numerous single nucleotide polymorphisms (SNPs) have been identified in CPB2, the gene encoding TAFI, and are located in the 5'-flanking region, in the coding …

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Effect of the G-308A polymorphism of the tumor necrosis factor α gene on the risk of ischemic heart disease and ischemic stroke: A meta-analysis

Tiago Pereira, Martina Rudnicki, Rendrik F. Franco, Alexandre C. Pereira et autres

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Do polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene affect the risk of childhood acute lymphoblastic leukemia?

Tiago Pereira, Martina Rudnicki, Alexandre C. Pereira, Maria S. Pombo‐de‐Oliveira et autres

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Cytokine gene variants and venous thrombotic risk in the BRATROS (BRAZILIAN THROMBOSIS STUDY)

Fabiano Pieroni, Dayse Maria Lourenço, Vânia M. Morelli, Francisco Humberto de Abreu Maffei et autres

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5,10-Methylenetetrahydrofolate Reductase Polymorphisms and Acute Lymphoblastic Leukemia Risk: A Meta-analysis

Tiago Pereira, Martina Rudnicki, Alexandre C. Pereira, Maria S. Pombo‐de‐Oliveira et autres

There is evidence supporting a role for 5-10 methylenetetrahydrofolate reductase (MTHFR) gene variants in acute lymphoblastic leukemia (ALL). To provide a more robust estimate of the effect of MTHFR polymorphisms on the risk of ALL, we did a meta-analysis to reevaluate the …

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A transcobalamin gene polymorphism and the risk of venous thrombosis. The BRATROS (Brazilian Thrombosis Study)

Ana Carolina Pereira, Dayse Maria Lourenço, Francisco Humberto de Abreu Maffei, Vânia M. Morelli et autres

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