2026
conference-abstract
OpenAlex
Dana J. Ruminski Lowe, R Howard, Serene Roque, Praveena Kamineni et autres
Abstract Next generation sequencing (NGS) assays and other advanced genomic techniques for tumor profiling require sufficient and high-quality nucleic acid input. Formalin fixed and paraffin embedded (FFPE) samples are a common, yet challenging type of patient sample often used in these tests. …
us
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Accès ouvert
2025
preprint
OpenAlex
A. Liu, Zhucong Xi, Xiaobo Chen, Catherine Huang et autres
Understanding the atomic-scale mechanisms governing metal-mediated nucleation and growth of gallium nitride (GaN) and related alloys is critical for tailoring their structural and functional properties in advanced electronic, optoelectronic, and quantum devices. Using real-time environmental transmission electron microscopy (E-TEM) in conjunction with …
Accès ouvert
2025
conference-abstract
OpenAlex
Catherine Huang, Dana Ruminski Lowe, Jasmine Raposa, Eric Morreale et autres
Abstract Background Influenza A H5N1 is a highly pathogenic avian influenza virus strain that poses a significant threat to global public health due to its potential to cause severe illness and widespread outbreaks in both humans and animals. While transmission of H5N1 …
us
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2025
conference-abstract
OpenAlex
Dana Ruminski Lowe, R Howard, Edward S. Davis, Andrew Anfora et autres
Formalin fixed and paraffin embedded (FFPE) samples are a common, yet challenging type of patient sample in comprehensive genomic profiling (CGP). DNA extracted from FFPE is often highly cross-linked, degraded, and fragmented. Yield from patient samples can also be limited, thus optimization …
us
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2025
conference-abstract
OpenAlex
Dana Ruminski Lowe, Deepika Philkana, Krystyna Nahlik, Melissa Berenger et autres
Abstract Up to 10% of all cancers may be caused by inherited genetic changes. Consequently, the increasing prevalence of cancer is driving the growth of the hereditary cancer testing as it is important to implement surveillance and risk-reduction strategies, detect cancer at …
us
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2024
conference-abstract
OpenAlex
Alysha N. Higgs, Angelique Ryan, Jayanthi Ramprakash, Dana Ruminski Lowe et autres
Abstract Aberrant DNA methylation is associated with many cancers including breast, liver, bone, and colon and has been identified as a biomarker for early cancer screening. Liquid biopsies are beginning to screen for DNA methylation in cancer-derived DNA, but accurate assessment of …
de
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2024
conference-abstract
OpenAlex
Dana Ruminski Lowe, Sanchita Jamindar, Yves Konigshofer, Andrew Anfora et autres
Abstract Liquid biopsy testing has grown to support early disease diagnosis, therapy selection, and disease and treatment surveillance in cancer survivors. Recent advances in next generation sequencing (NGS) have enabled larger panel sizes, pan-cancer target sets, and wider ranges of genomic alterations. …
de
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2024
conference-abstract
OpenAlex
Dana Ruminski Lowe, Sanchita Jamindar, Andrew Anfora, David Merriam et autres
Abstract Extraction of cell free DNA (cfDNA) from a patient’s blood sample is a crucial preanalytic step of the liquid biopsy process. Whether testing is being performed for early disease diagnosis, therapy selection, or disease and treatment surveillance, the input material must …
de
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Accès ouvert
2023
report
OpenAlex
Kenechukwu Anadu, Pablo Azar, Marco Cipriani, Thomas M. Eisenbach et autres
Stablecoins and money market funds both seek to provide investors with safe, money-like assets but are vulnerable to runs in times of stress.In this paper, we investigate similarities and differences between the two, comparing investor behavior during the stablecoin runs of 2022 …
us
(code pays fourni par la source)
Accès ouvert
2023
report
OpenAlex
Kenechukwu Anadu, Pablo Azar, Marco Cipriani, Thomas M. Eisenbach et autres
Stablecoins and money market funds both seek to provide investors with safe, money-like assets but are vulnerable to runs in times of stress. In this paper, we investigate similarities and differences between the two, comparing investor behavior during the stablecoin runs of …
us
(code pays fourni par la source)
2023
conference-abstract
OpenAlex
Dana Ruminski Lowe, Robert Whiting, Matthew G. Butler, Yves Konigshofer et autres
Abstract Homologous recombination deficiency (HRD) arises when defects in DNA repair pathways occur, leading to genomic instability. HRD status is an emerging therapeutic biomarker; NGS assays that measure it can be used to stratify ovarian and breast cancer patients and determine eligibility …
de
(code pays fourni par la source)
2023
conference-abstract
OpenAlex
Dana Ruminski Lowe, Benedicta Forson, Maria Cowen, Matthew G. Butler et autres
Abstract Mutations in the tumor suppressor BRCA1 and BRCA2 genes can cause cell damage that significantly increases the risk of developing breast, ovarian, prostate, and pancreatic cancers. Large genomic rearrangements (LGRs) are defined as deletions, duplications or insertions; often involving a significant …
de
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