L. Jay Katz

Early adoption of a novel initial treatment paradigm for open-angle glaucoma: an evidence-based model

J. Morgan Micheletti, Christine M. Funke, Nathan M. Radcliffe, Dana M. Hornbeak et autres

Introduction Glaucoma treatment is transitioning from a reflexive topical-medication-first approach to a proactive, procedure-based strategy of earlier laser, minimally-invasive glaucoma surgery (MIGS), and/or sustained-release procedural pharmaceuticals with the aim of improving quality of life and minimizing the burden of daily compliance – …

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Administration of the Travoprost Intracameral Implant in an Office-Based Surgery Setting

Inder Paul Singh, George R. Reiss, Brian E. Flowers, L. Jay Katz et autres

INTRODUCTION: The purpose of this analysis was to assess the safety outcomes of a subgroup of patients who received a travoprost intracameral implant in an office-based surgery setting from one of the phase 3 registration trials, GC-012, for the implant. METHODS: Adult …

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Six-Month Outcomes from a Prospective, Randomized Study of iStent infinite Versus Hydrus in Open-Angle Glaucoma: The INTEGRITY Study

Iqbal Ike K. Ahmed, John Palmer Berdahl, Arkadiy Yadgarov, George R. Reiss et autres

INTRODUCTION: This was a prospective, randomized, double-masked, multicenter, 24-month study to compare effectiveness and safety outcomes following standalone implantation of two types of current generation trabecular stents in adults with open-angle glaucoma (OAG). An interim analysis was performed at month 6. METHODS: …

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Safety and efficacy of travoprost intracameral implant administered in combination with cataract surgery

Inder Paul Singh, Lilit A. Voskanyan, Kevin M. Barber, James H. Burden et autres

Background: The travoprost intracameral implant and cataract surgery both lower intraocular pressure (IOP). Objectives: We evaluated the safety and IOP-lowering effect at 3 months following administration of travoprost intracameral implant in combination with cataract surgery. Design: Prospective, 12-month, open-label, single-arm trial. Methods: …

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Long-Term Safety and Efficacy Evaluation of Travoprost Intracameral Implant Based on Pooled Analyses from Two Phase III Trials

Inder Paul Singh, John Palmer Berdahl, Steven R. Sarkisian, Lilit A. Voskanyan et autres

AIM: The purpose of this study was to conduct and interpret a pooled 12-month analysis of two prospective, multi-center, randomized, double-masked, controlled trials designed to assess the efficacy and safety of the travoprost intracameral implant (slow-eluting [SE] implant in development as a …

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Travoprost Intracameral Implant Demonstrates Superior IOP Lowering Versus Topical Prostaglandin Analog Monotherapy in Patients with Open-Angle Glaucoma or Ocular Hypertension

Jason Bacharach, Long V. Doan, Kerry G. Stephens, Dale W. Usner et autres

INTRODUCTION: This study was conducted to analyze and compare the intraocular pressure (IOP) treatment effect of the slow-eluting (SE) travoprost intracameral implant to the IOP treatment effect of topical prostaglandin analog (PGA) monotherapy in a subgroup of subjects who were on pre-study …

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Intraocular pressure profile following selective laser trabeculoplasty in pigmentary and primary open-angle glaucoma

Shahin Hallaj, Sapna Sinha, Nikki A. Mehran, Amber M Morrill et autres

PURPOSE: To compare the intraocular pressure (IOP) profile and the incidence of IOP spikes following selective laser trabeculoplasty (SLT) between pigmentary glaucoma (PG) and primary open-angle glaucoma (POAG). MATERIALS AND METHODS: Retrospective comparative study of 65 PG eyes of 51 patients matched …

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Contemporary Approach to Narrow Angles

Wesam Shamseldin Shalaby, Rohit Reddy, Reza Razeghinejad, L. Jay Katz

Glaucoma is the leading cause of irreversible blindness worldwide. Among all glaucoma types, primary angle closure glaucoma (PACG) affects approximately 23 million people worldwide, and is responsible for 50% of glaucoma-related blindness, highlighting the devastating consequences of this disease. The main mechanism …

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Phase 3 Randomized Clinical Trial of the Safety and Efficacy of Travoprost Intraocular Implant in Patients with Open-Angle Glaucoma or Ocular Hypertension

Steven R. Sarkisian, Robert Edward T. Ang, Andy M. Lee, John Palmer Berdahl et autres

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Travoprost Intracameral Implant for Open-Angle Glaucoma or Ocular Hypertension: 12-Month Results of a Randomized, Double-Masked Trial

Steven R. Sarkisian, Robert Edward T. Ang, Andy M. Lee, John Palmer Berdahl et autres

INTRODUCTION: This prospective, multicenter, randomized, double-masked pivotal phase 3 trial evaluated the efficacy and safety of the travoprost intracameral SE-implant (slow-eluting implant, the intended commercial product) and FE-implant (fast-eluting implant, included primarily for masking purposes) compared to twice-daily (BID) timolol ophthalmic solution, …

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Efficacy and Safety of the Travoprost Intraocular Implant in Reducing Topical IOP-Lowering Medication Burden in Patients with Open-Angle Glaucoma or Ocular Hypertension

John Palmer Berdahl, Steven R. Sarkisian, Robert Edward T. Ang, Long V. Doan et autres

PURPOSE: A randomized, double-masked, multicenter, phase 2 trial to evaluate the long-term safety and efficacy of travoprost intraocular implant, an extended-release drug delivery system designed to provide uninterrupted sustained intraocular pressure (IOP)-lowering therapy, thereby reducing patient treatment burden and improving adherence with …

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Changing from preserved, to preservative-free cyclosporine 0.1% enhanced triple glaucoma therapy: impact on ocular surface disease—a randomized controlled trial

Anastasios-Georgios P. Konstas, Kostas G. Boboridis, Georgios P Athanasopoulos, Anna‐Bettina Haidich et autres

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