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Nadim Mahmud, C. Burcin Taner, Nasimul Ahsan
To function as effector cells, T cells must undergo antigen-stimulated activation that induces synthesis of many lymphokines, including interleukin-2 (IL-2). In certain diseases, a proportion of these stimulated cells will express surface interleukin-2 receptor (IL-2R) alpha peptide, and in these conditions the …
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Nasimul Ahsan, Syed K. Rafi, Beate Lanske, Mohammed Shawkat Razzaque
Although vitamin D is commonly perceived as a bone-forming vitamin, it in fact exerts numerous essential physiological functions ranging from the maintenance of mineral ion homeostasis to the regulation of the immune system [1-5]. The synthesis of vitamin D is a complex …
Ahsan A. Ejaz, Abdo Asmar, Mourad M. Alsabbagh, Nasimul Ahsan
Experimental data suggest that the B-cell antigen CD20 may play a significant role in the pathogenesis of many diseases including glomerular diseases. These and other findings underpin the central concept of B-cell-depleting therapies that target CD20 antigen as treatments for lupus nephritis, …
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Dusko Klipa, Nadim Mahmud, Nasimul Ahsan
The use of antibodies in transplantation dates to 1986 when muromonab CD3, a monoclonal antibody (mAb) targeting CD3, was first approved for prevention and treatment of renal allograft rejection. These agents have largely been used in a brief adjunctive manner to provide …
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Nadim Mahmud, Dusko Klipa, Nasimul Ahsan
Currently, a wide variety of both polyclonal and monoclonal antibodies are being routinely utilized to prevent and treat solid organ rejection. More commonly, these agents are also administered in order to delay introduction of calcineurin inhibitors, especially in patients with already compromised …
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Jaime Aranda‐Michel, Nasimul Ahsan
Background: Organ transplantation is a life saving procedure in patients with end-organ disease. While improvement in surgical techniques made transplantation possible in the 1960s, advances in immunosuppressive therapies have resulted in lower rates of acute cellular rejection and consequently, significant improvements in …
Nasimul Ahsan, Hani M. Wadei, Petrina V. Genco, Xochiquetzal J. Geiger et autres
BACKGROUND: Timely transplantation of sensitized kidney recipients remains a challenge. Patients with a complement-dependent cytotoxicity negative and flow cytometry (FC) positive crossmatch carry increased risk of antibody-mediated rejection and thus graft loss. Solid phase assays are available to confirm donor specificity for …
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One mark of success in organ transplantation is the attempt to reduce maintenance immunosuppression. This change in direction from maximizing therapy to exploring alternatives of minimizing drug treatment to prevent rejection is predicated on the success of current regimens to reduce rejection. …
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Virginia C. Hall, Nasimul Ahsan, James H. Keeling
We present a case of larva currens in a patient scheduled for renal transplant. Larva currens is an eruption caused by Strongyloides stercoralis, characterized most often by a pathognomonic, migratory, rapidly extending, serpiginous, urticarial eruption. Infected patients who are immunocompromised are at …
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Julie Roskopf, Jennifer Trofe, Robert J. Stratta, Nasimul Ahsan
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