Michael D. Mendenhall

Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats

Hilaree N. Frazier, Katie L. Anderson, Adam O. Ghoweri, Ruei‐Lung Lin et autres

As demonstrated by increased hippocampal insulin receptor density following learning in animal models and decreased insulin signaling, receptor density, and memory decline in aging and Alzheimer's diseases, numerous studies have emphasized the importance of insulin in learning and memory processes. This has …

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Elevating Insulin Signaling Using a Constitutively Active Insulin Receptor Increases Glucose Metabolism and Expression of GLUT3 in Hippocampal Neurons

Hilaree N. Frazier, Adam O. Ghoweri, Katie L. Anderson, Ruei‐Lung Lin et autres

Insulin signaling is an integral component of healthy brain function, with evidence of positive insulin-mediated alterations in synaptic integrity, cerebral blood flow, inflammation, and memory. However, the specific pathways targeted by this peptide remain unclear. Previously, our lab used a molecular approach …

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Platelets Endocytose Viral Particles and Are Activated via TLR (Toll-Like Receptor) Signaling

Meenakshi Banerjee, Yunjie Huang, Smita N. Joshi, Gabriel J. Popa et autres

Objective: Thrombocytopenia is associated with many viral infections suggesting virions interact with and affect platelets. Consistently, viral particles are seen inside platelets, and platelet activation markers are detected in viremic patients. In this article, we sought mechanistic insights into these virion/platelet interactions …

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Expression of a Constitutively Active Human Insulin Receptor in Hippocampal Neurons Does Not Alter VGCC Currents

Hilaree N. Frazier, Katie L. Anderson, Sigandan Maimaiti, Adam O. Ghoweri et autres

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Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice

Clare H Latta, Tiffany L. Sudduth, Erica M. Weekman, Holly M. Brothers et autres

BACKGROUND: Microglia are considered the resident immune cells of the central nervous system (CNS). In response to harmful stimuli, an inflammatory reaction ensues in which microglia are activated in a sequenced spectrum of pro- and antiinflammatory phenotypes that are akin to the …

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Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice

Erica M. Weekman, Tiffany L. Sudduth, Gabriel J. Popa, Michael D. Mendenhall et autres

BACKGROUND: The polarization to different neuroinflammatory phenotypes has been described in early Alzheimer's disease, yet the impact of these phenotypes on amyloid-beta (Aβ) pathology remains unknown. Short-term studies show that induction of an M1 neuroinflammatory phenotype reduces Aβ, but long-term studies have …

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Elongin C is a mediator of Notch4 activity in human renal tubule cells

Timothy D. Cummins, Michael D. Mendenhall, Michelle N. Lowry, Erik A. Korte et autres

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Signal Transduction Protocols

Robert C. Dickson, Michael D. Mendenhall

In 1995, Signal Transduction Protocols, edited by David A. Kendall and Stephen J. Hill, was published in the Methods in Molecular Biology series. This second edition represents an update to that previ

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The CdtB subunit of cytolethal distending toxin is a DNase-related protein that causes chromosome damage in vivo

Duane C. Hassane, R. B. Lee, Michael D. Mendenhall, Carol L. Pickett

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

Piers Nash, Xiaojing Tang, Stephen M. Orlicky, Qinghua Chen et autres

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Cytolethal Distending Toxin Demonstrates Genotoxic Activity in a Yeast Model

Duane C. Hassane, Robert B. Lee, Michael D. Mendenhall, Carol L. Pickett

Cytolethal distending toxins (CDTs) are multisubunit proteins produced by a variety of bacterial pathogens that cause enlargement, cell cycle arrest, and apoptosis in mammalian cells. While their function remains uncertain, recent studies suggest that they can act as intracellular DNases in mammalian …

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Regulation of Cdc28 Cyclin-Dependent Protein Kinase Activity during the Cell Cycle of the Yeast Saccharomyces cerevisiae

Michael D. Mendenhall, Amy E. Hodge

The cyclin-dependent protein kinase (CDK) encoded by CDC28 is the master regulator of cell division in the budding yeast Saccharomyces cerevisiae. By mechanisms that, for the most part, remain to be delineated, Cdc28 activity controls the timing of mitotic commitment, bud initiation, …

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