H. Donald Burns

Vibrato use in contemporary performance of Paul Hindemith’s sonata for Solo Viola, Op. 25 No. 1

H. Donald Burns

INTIMATE MACHINES: Cultivating Wisdom in Elder Gardens

H. Donald Burns

Because the full study is published elsewhere (Marcellino 2019), we present here only selected results from

Theresa Jarnagin Enos, In Memoriam

Elise Verzosa Hurley, Richard Leo Enos, Peter H. Elbow, John W. Warnock et autres

On November 2, 2016, Theresa Jarnagin Enos unexpectedly passed away at her home in Tucson, Arizona, leaving behind a trailblazing legacy of work in writing, teaching, scholarly editing, (wo)mentori...

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MINUTES OF MEETING SUSTAINABLE TRANSPORT ADVISORY COMMITTEE

H. Donald Burns, Jonathan Gunn, Richard Green, Melisa Palermo et autres

Evaluation of [18F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human

Eric D. Hostetler, Sandra Sanabria Bohórquez, Waisi Eng, Aniket D. Joshi et autres

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Synthesis, characterization, and monkey positron emission tomography (PET) studies of [18F]Y1-973, a PET tracer for the neuropeptide Y Y1 receptor

Eric D. Hostetler, Sandra Sanabria Bohórquez, Hong Song Fan, Zhizhen Zeng et autres

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Occupancy of human brain GABAA receptors by the novel α5 subtype-selective benzodiazepine site inverse agonist α5IA as measured using [11C]flumazenil PET imaging

Waisi Eng, John R. Atack, Mats Bergström, Sandra Sanabria et autres

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The synthesis and preclinical evaluation in rhesus monkey of [18F]MK‐6577 and [11C]CMPyPB glycine transporter 1 positron emission tomography radiotracers

Terence G. Hamill, Waisi Eng, Andrew S. R. Jennings, Richard I. Lewis et autres

Two positron emission tomography radiotracers for the glycine transporter 1 (GlyT1) are reported here. Each radiotracer is a propylsulfonamide-containing benzamide and was labeled with either carbon-11 or fluorine-18. [¹¹C]CMPyPB was synthesized by the alkylation of a 3-hydroxypyridine precursor using [¹¹C]MeI, and [¹⁸F]MK-6577 …

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Characterization of [18F]Y1-973, a novel PET tracer for the neuropeptide Y Y1 receptor (NPY Y1), in rhesus monkey

Eric D. Hostetler, Sandra Sanabria, Hong Song Fan, Minoru Kameda et autres

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Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1

Wesley Blackaby, Richard T. Lewis, Joanne L. Thomson, Andrew S. R. Jennings et autres

Amalgamation of the structure-activity relationship of two series of GlyT1 inhibitors developed at Merck led to the discovery of a clinical candidate, compound 16 (DCCCyB), which demonstrated excellent in vivo occupancy of GlyT1 transporters in rhesus monkey as determined by displacement of …

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Synthesis, characterization, and monkey PET studies of [18F]MK‐1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK‐5435

Eric D. Hostetler, Waisi Eng, Aniket D. Joshi, Sandra Sanabria Bohórquez et autres

Two moderately lipophilic, high affinity ligands for metabotropic glutamate receptor subtype 1 (mGluR1) were radiolabeled with a positron-emitting radioisotope and evaluated in rhesus monkey as potential PET tracers. Both ligands were radiolabeled with fluorine-18 via nucleophilic displacement of the corresponding 2-chloropyridine precursor …

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Radiosynthesis of the HIV integrase inhibitor [18F]MK‐0518 (Isentress)

Wenping Li, Wayne J. Thompson, Thorsten E. Fisher, John S. M. Wai et autres

Abstract The human immunodeficiency virus integrase inhibitor, [18F]MK‐0518, was prepared via a three‐step, one‐pot radiosynthesis. [18F]4‐Fluorobenzylamine was produced from the fluorination of 4‐cyano‐N,N,N‐trimethylammonium triflate with [18F]fluoride and reduction with borane methylsulfide complex in 50–68% radiochemical yield. The final step, the coupling of …

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