J. J. S. Schwarz

Bone Marrow Histology Characteristics in MPL515 Mutated Thrombocythemia with Various Degrees of Myelofibrosis: A Cross Sectional Follow-up Study in Eight Cases

Jan Jacques Michiels, De Raeve H, J. J. S. Schwarz, Vít Campr et autres

MPLW515l/K mutated Essential Thrombocythemia (ET) usually present with increased platelet counts around 1000 x 109/L as the only abnormal laboratory finding with normal values for hemoglobin and leukocytes and minor splenomegaly on palpation only in a few. Early stage MPL515 mutated ET …

The structure and basic properties of iron zinc metaphosphate glasses

Petr Hejda, Jana Holubová, Zdeněk Černošek, J. J. S. Schwarz et autres

Antiplatelet therapy versus observation in low-risk essential thrombocythemia with a CALR mutation

Alberto Álvarez‐Larrán, Arturo Pereira, Paola Guglielmelli, Juan Carlos Hernández‐Boluda et autres

The role of antiplatelet therapy as primary prophylaxis of thrombosis in low-risk essential thrombocythemia has not been studied in randomized clinical trials. We assessed the benefit/risk of low-dose aspirin in 433 patients with low-risk essential thrombocythemia (271 with a CALR mutation, 162 …

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The impact of thrombophilia in the management of MPN

J. J. S. Schwarz

Aktualizovaná doporučení pro diagnostiku a léčbu chronické lympfocytární leukémie (CLL) české CLL skupiny.

Lukáš Smolej, Martin Špaček, Petra Obrtlíková, Šárka Pospı́šilová et autres

[The effectiveness of anagrelide treatment in patients with Ph negative myeloproliferative diseases: influence on the incidence of thrombosis in the data from the Registry of patients with essential thrombocythemia and thrombocythemia associated with other myeloproliferative diseases treated with Thromboreductin® to the end of 2012].

Miroslav Penka, J. J. S. Schwarz, Petra Ovesná, Libor Červínek et autres

In the Czech Republic, anagrelide (Thromboreductin®) [29] is used according to the recommendations of the Czech Working Group on Myeloproliferative Disorders (CZEMP) for treatment of thrombocythemia associated with Ph negative myeloproliferative disorders (MPDs). The patient data are collected in the Registry of …

Real-time PCR quantification of major Wilms’ tumor gene 1 (WT1) isoforms in acute myeloid leukemia, their characteristic expression patterns and possible functional consequences

Karolina Škvárová Kramarzová, Jan Stuchlý, Andre Manfred Willasch, Bernd Gruhn et autres

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[Summary of recommendations for the diagnosis and therapy of BCR/ABL-negative myeloproliferation of the Czech Working Group for Ph-negative myeloproliferative disease (CZEMP) of the Czech Hematologic Society CLS JEP ].

Miroslav Penka, J. J. S. Schwarz, Vít Campr, Dagmar Pospı́šilová et autres

[Diagnosis and treatment of BCR/ABL-negative myeloproliferative diseases--principles and rationale of CZEMP recommendations].

J. J. S. Schwarz, Miroslav Penka, Vít Campr, Dagmar Pospı́šilová et autres

In 2009, the recommendations of the Czech Collaborative Group for Ph- Myeloproliferative Diseases (CZEMP) for diagnosis and treatment of BCR/ABL-negative myeloproliferative diseases (MPD), i.e., essential thrombocythemia (ET), polycythaemia vera (PV) and primary myelofibrosis (PMF) were updated and extended. The present article gives …

The effect of allogeneic stem cell transplantation on high risk chronic lymphocytic leukaemia: a single centre retrospective analysis

Veronika Válková, J. J. S. Schwarz, Antonı́n Vı́tek, Markéta Marková et autres

In recent years, many studies have confirmed that allogeneic stem cell transplantation (allo-SCT) can provide long-term disease control and possible cure in selected patients with chronic lymphocytic leukaemia (CLL), including those with a biologically highly unfavourable risk profile. A retrospective analysis of …

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[Essential thrombocythaemia and other myeloproliferative disorders with thrombocythaemia treated with Thromboreductin. A report from the database of register for the 1st quarter of 2010].

Miroslav Penka, J. J. S. Schwarz, Petra Ovesná, Antonín Hluší et autres

In the Czech Republic, anagrelid is used according to the recommendations of the Czech Working Group on Myeloproliferative Disorders for treatment ofthrombocythaemias associated with chronic myeloproliferative disorders--mainly essential thrombocythaemia and, regularly, reports are being presented from the Register of Patients Treated with …

Advanced Rai Stage in Patients with Chronic Lymphocytic Leukaemia Correlates with Simultaneous Hypermethylation of Plural Tumour Suppressor Genes

Kristina Forsterová, Hana Votavová, J. J. S. Schwarz, Josef Karban et autres

Hypermethylation of CpG islands within gene promoters is one of various mechanisms of gene silencing involved in the pathogenesis of human cancer. By using methylation-specific polymerase chain reaction we explored aberrant promoter methylation of five tumour suppressor genes in 29 patients with …

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