Horst L. Fehm

Untersuchungen zur Hyperemesis gravidarum

A Wolf, K. Musch, Horst L. Fehm, C Lauritzen

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Hypothalamus-pituitary-adrenal activity during human sleep: A coordinating role for the limbic hippocampal system

Jan Born, Horst L. Fehm

This review focuses on experiments in humans examining the regulation of the hypothalamo-pituitary-adrenal (HPA) system during nocturnal sleep. The HPA system is a most important mediator of the organism's response to stress. The early phase of nocturnal sleep dominated by extended epochs …

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Evidence for Central Nervous Effects of Corticotropin-Releasing Hormone on Gastric Acid Secretion in Humans

Werner Kern, Bernhard Schiefer, Jürgen Schwarzenburg, Eduard F. Stange et autres

In animals, corticotropin-releasing hormone (CRH) has been shown to decrease gastric acid secretion after intracerebral administration. Evidence exists that in man peptides have a direct access to the brain upon intranasal administration. This study aimed at assessing brain-mediated effects of CRH on …

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Time Course of ACTH 4–10 Effects on Human Attention

Jan Born, Ulrike Unseld, Reinhard Pietrowsky, Ulrich Bickel et autres

Previous studies have demonstrated that the adrenocorticotropic hormone (ACTH) and its 4-10 fragment are potent modulators of attention in humans. In these studies the Nd component ('negative displacement') of the stimulus-evoked brain potential (event-related potential, ERP), which is a neurophysiological indicator of …

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Announcement / Erratum

William F. Silverman, Paul A. Aravich, John R. Sladek, Celia D. Sladek et autres

The Charles E. Culpeper

Diagnose eines Ullrich-Turner-Syndroms im Rentengutachten

Burkhard Kreft, M. Greiwe, M. Schreiber, G Wiedemann et autres

A 56-year-old woman of short stature (148 cm) was medically examined after applying for a disability pension on account of chronic back-pain. She gave a history of primary amenorrhoea (not examined further), slowly increasing deafness, type IIb diabetes mellitus, hyperlipoproteinaemia, hypothyroidism and …

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Influences of the Cholecystokinin Analog Ceruletide on Human Sleep and Evoked Potentials

Reinhard Pietrowsky, Horst L. Fehm, Adair Er, B. Bathelt et autres

Two experiments are reported, investigating the effects of the cholecystokinin analog ceruletide on central nervous activation in man. In experiment I, 0.55 micrograms/h ceruletide was infused at a constant rate during the night to study its effects on spontaneous EEG activity during …

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Influences of Cortisol on Auditory Evoked Potentials (AEPs) and Mood in Humans

Jan Born, V. Hitzler, Reinhard Pietrowsky, P. Pauschinger et autres

The present study was designed to investigate effects of cortisol on evoked potential indicators of sensory processing and on mood in 45 healthy human subjects. In order to determine the glucocorticoid effect to be primary excitatory or inhibitory, the vertex potential components. …

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Influences of Corticosteroids, Dexamethasone and Hydrocortisone on Sleep in Humans

Horst L. Fehm, R. Benkowitsch, W. Kern, Gabriele Fehm‐Wolfsdorf et autres

The present two experiments were designed to investigate the effects of a synthetic and of a natural corticosteroid on nocturnal sleep in humans. Both experiments were held double-blind and designed according to a within-subject cross-over comparison. In the first experiment, 1 mg …

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Differential energetic response of brain vs. skeletal muscle upon hyperglycemia in humans

Kerstin M. Oltmanns, U Melchert, Harald G. Scholand-Engler, Maria C. Howitz et autres

Objectives: The brain aims to maintain its energy content at a highly stable level. During acute hypoglycemia, high energy phosphate concentrations of the brain remain constant while there is a decrease in skeletal muscle. Accordingly, we assumed a differential energetic response of …

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Defective Awakening Response to Nocturnal Hypoglycemia in Patients with Type 1 Diabetes Mellitus

Bernd Schultes, Kamila Jauch‐Chara, Steffen Gais, Manfred Hallschmid et autres

BACKGROUND: Nocturnal hypoglycemia frequently occurs in patients with type 1 diabetes mellitus (T1DM). It can be fatal and is believed to promote the development of the hypoglycemia-unawareness syndrome. Whether hypoglycemia normally provokes awakening from sleep in individuals who do not have diabetes, …

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Causes of obesity: Looking beyond the hypothalamus

Achim Peters, Luc Pellerin, M DALLMAN, Kerstin M. Oltmanns et autres

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