P.M. Kluin

Diffuse large B cell lymphomas relapsing in the CNS lack oncogenic MYD88 and CD79B mutations

Marie José Kersten, Willem Kraan, Jeanette K. Doorduijn, Jacoline E. C. Bromberg et autres

Pasqualucci L . The genetic basis of diffuse large B-cell lymphoma. Curr Opin Hematol 2013; 20 : 336–344. Article CAS Google Scholar Ziepert M, Hasenclever D, Kuhnt E, Glass B, Schmitz N, Pfreundschuh M et al . Standard international prognostic index remains …

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High prevalence of oncogenic MYD88 and CD79B mutations in diffuse large B-cell lymphomas presenting at immune-privileged sites

Willem Kraan, Hugo M. Horlings, Martine van Keimpema, Esther J.M. Schilder-Tol et autres

Activating mutations in CD79 and MYD88 have recently been found in a subset of diffuse large B-cell lymphoma (DLBCL), identifying B-cell receptor and MYD88 signalling as potential therapeutic targets for personalized treatment. Here, we report the prevalence of CD79B and MYD88 mutations …

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A single center analysis of nucleophosmin in acute myeloid leukemia: value of combining immunohistochemistry with molecular mutation analysis

Carolien M. Woolthuis, André B. Mulder, Rikst Nynke Verkaik‐Schakel, S. Rosati et autres

Mutations of nucleophosmin 1 are frequently found in acute myeloid leukemia and lead to aberrant cytoplasmic accumulation of nucleophosmin protein. Immunohistochemical staining is therefore recommended as the technique of choice in front-line screening. In this study, we assessed the sensitivity and specificity …

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FADD expression is associated with regional and distant metastasis in squamous cell carcinoma of the head and neck

Wouter J. Pattje, Lieuwe J. Melchers, Lorian Slagter‐Menkema, M F Mastik et autres

AIMS: The Fas-associated death domain gene (FADD) is often overexpressed in squamous cell carcinoma of the head and neck (HNSCC), and is considered to be a driver gene in amplification of the chromosomal 11q13.3 region. Amplification of 11q13.3 is associated with increased …

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Contribution of highly sensitive diagnostic methods to the diagnosis of systemic mastocytosis in the absence of skin lesions

Iván Álvarez‐Twöse, Almudena Matito, Laura Sánchez‐Muñoz, José Mário Morgado et autres

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Tryptase and histamine metabolites as diagnostic indicators of indolent systemic mastocytosis without skin lesions

Jaap J. van Doormaal, Eveline van der Veer, Pieter C. van Voorst Vader, P.M. Kluin et autres

BACKGROUND: Risk indicators of indolent systemic mastocytosis (ISM) in adults with clinical suspicion of ISM without accompanying skin lesions [urticaria pigmentosa (UP)] are lacking. This study aimed at creating a decision tree using clinical characteristics, serum tryptase, and the urinary histamine metabolites …

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Downregulation of MEIS1 impairs long-term expansion of CD34+ NPM1-mutated acute myeloid leukemia cells

Carolien M. Woolthuis, Rikst Nynke Verkaik‐Schakel, Djoke van Gosliga, P.M. Kluin et autres

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Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML

Hendrik J.M. de Jonge, Carolien M. Woolthuis, AnneMarie Vos, André B. Mulder et autres

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Gene Expression Profiling In Leukemic Stem Cell-Enriched AML CD34+ Cell Fraction Identifies Target Genes That Predict Prognosis In Normal Karyotype AML

Carolien M. Woolthuis, Hendrik J.M. de Jonge, Annet Z Vos, André B. Mulder et autres

Abstract Abstract 952 Acute myeloid leukemia (AML) is clinically, cytogenetically and molecularly a heterogeneous disease which makes it challenging to classify it properly. In recent years major advances have been achieved in predicting outcome. However, there is still need for more powerful …

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Virtual microscopy: Merging of computer mediated collaboration and intuitive interfacing

Huib de Ridder, Johanna G. de Ridder-Sluiter, P.M. Kluin, Henri Christiaans

Ubiquitous computing (or Ambient Intelligence) is an upcoming technology that is usually associated with futuristic smart environments in which information is available anytime anywhere and with which humans can interact in a natural, multimodal way. However spectacular the corresponding scenarios may be, …

Overexpression of Intrinsic Hypoxia Markers HIF1α and CA-IX Predict for Local Recurrence in Stage T1-T2 Glottic Laryngeal Carcinoma Treated With Radiotherapy

Michiel L. Schrijvers, Bernard F. A. M. van der Laan, Geertruida H. de Bock, Wouter J. Pattje et autres

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Detection of trisomy 8 in hematological disorders by in situ hybridization

Robert E. Kibbelaar, Harmen Van Kamp, EJ Dreef, J.W. Wessels et autres

An alphoid repetitive DNA (D8Z2) probe specific for the pericentromeric region of chromosome 8 was used to detect extra copies of chromosome 8 in bone marrow cells obtained from 10 patients with hematological disorders and five controls. Numerical aberrations of chromosome 8 …

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