Yuzhou Bao

sc-eQTL unveil Immunogenetic Architecture of Polycystic Ovary Syndrome

Xiaoqian Xu, Yuzhou Bao, Qi Zhang, Hao Wang et autres

cn, us (code pays fourni par la source)

Themis differentially regulates T follicular helper cell differentiation during early and late stages of chronic viral infection

Yuzhen Zhu, Yuzhou Bao, Ning Wang, Qifeng Gan et autres

Introduction: T follicular helper (TFH) cells are critical for humoral immunity during chronic viral infection, but the mechanisms guiding their differentiation from a novel CD4⁺ T cell progenitors remain incompletely understood. Themis, a T cell-specific adaptor protein, has been implicated in T …

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Themis dominates T cell exhaustion by regulation of TCR and PD-1 signaling

Jian Tang, Xian Jia, Taoling Zeng, Yuzhou Bao et autres

Abstract T cell exhaustion is important to protect the host from immunopathology during chronic viral infection, but it also impairs T cell anti-tumor immunity 1–5 . A fundamental unresolved question is whether and how T cell exhaustion is determined at the onset …

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Approaches for studying human macrophages

Yuzhou Bao, Guanlin Wang, Hanjie Li

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SHP-1 Regulates CD8+ T Cell Effector Function but Plays a Subtle Role with SHP-2 in T Cell Exhaustion Due to a Stage-Specific Nonredundant Functional Relay

Bowen Hou, Yanyan Hu, Yuzhen Zhu, Xiaocui Wang et autres

SHP-1 (Src homology region 2 domain-containing phosphatase 1) is a well-known negative regulator of T cells, whereas its close homolog SHP-2 is the long-recognized main signaling mediator of the PD-1 inhibitory pathway. However, recent studies have challenged the requirement of SHP-2 in …

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An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development

Zeshuai Wang, Zhisheng Wu, Hao Wang, Ruoqing Feng et autres

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Themis suppresses the effector function of CD8+ T cells in acute viral infection

Jian Tang, Xian Jia, Jian Li, Junchen Dong et autres

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10-4-4, A Cardiac Glycoside Block Growth in Cancer Cells via Nuclear Receptor Nur77 Mediated Na+/K+- ATPase Endocytosis

Mengjie Hu, Yang Xu, Yuzhou Bao, Jinshan Tang et autres

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Design and synthesis of biotinylated cardiac glycosides for probing Nur77 protein inducting pathway

Danmei Tian, Jia Qiao, Yuzhou Bao, Jie Liu et autres

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Modulation of the Nur77-Bcl-2 apoptotic pathway by p38α MAPK

Jie Liu, Guanghui Wang, Yinghui Duan, Yi Dai et autres

// Jie Liu 1, * , Guang-Hui Wang 1, * , Ying-Hui Duan 2 , Yi Dai 2 , Yuzhou Bao 1 , Mengjie Hu 1 , Yu-Qi Zhou 1 , Mingyu Li 1 , Fuquan Jiang 1 , Hu Zhou 1 …

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Synthesis of MeON-neoglycosides of digoxigenin with 6-deoxy- and 2,6-dideoxy-d-glucose derivatives and their anticancer activity

Dongdong Wang, Xiao-San Li, Yuzhou Bao, Jie Liu et autres

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Binding characterization, synthesis and biological evaluation of RXRα antagonists targeting the coactivator binding site

Dingyu Xu, Shangjie Guo, Ziwen Chen, Yuzhou Bao et autres

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