Youqin Tian

Evaluation of microparticles containing doxorubicin suitable for aerosol delivery to the lungs.

Youqin Tian, Melvin E. Klegerman, Anthony James Hickey

The efficacy of microparticulate systems containing anticancer agents may be assessed in vitro prior to evaluation of the effects of targeted and controlled drug release on tumor growth. Particles prepared in a size range suitable for aerosol delivery to the lungs (1-5 …

us, cn (code pays fourni par la source)

In Vitro Characterization of Polyorthoester Microparticles Containing Bupivacaine

Jone-Shin Deng, Luk Li, Youqin Tian, Eric J. Ginsburg et autres

Laboratory-scale spray-congealing equipment was utilized to fabricate injectable microparticles consisting of polyorthoester and bupivacaine. Operating conditions for the spray-congealing process were optimized to produce microparticles with the desired shape and particle size to yield acceptable syringeability and injectability. Characterizations were performed to …

gb, us (code pays fourni par la source)

The development of an injection-molding process for a polyanhydride implant containing gentamicin sulfate.

Jone-Shin Deng, Marts Meisters, Luk Li, Jeff Setesak et autres

A production-scale manufacturing process has been developed for polyanhydride/gentamicin sulfate implants for the treatment of osteomyelitis. Gentamicin sulfate was first dried to an acceptable moisture level by using a tumble vacuum dryer. Dried gentamicin sulfate powder and polyanhydride granules were separately fed …

us (code pays fourni par la source)

Effect of γ-radiation on a polyanhydride implant containing gentamicin sulfate

Jone-Shin Deng, Luk Li, Dennis A. Stephens, Youqin Tian et autres

us (code pays fourni par la source)

The Relationship Between Structures and In Vitro Properties of a Polyanhydride Implant Containing Gentamicin Sulfate

Jone-Shin Deng, Luk Li, Youqin Tian, Marts Meisters et autres

Laboratory scale injection-molding equipment was utilized to fabricate an implant consisting of poly(FAD:SA 1:1) and 20% (w/w) gentamicin sulfate. Characterizations were performed to determine the molecular weight and glass transition temperature of poly(FAD:SA 1:1). A study was carried out to investigate the …

us, gb (code pays fourni par la source)

Light-Scattering Method in Particle Size Analysis of Parenteral Emulsions

Youqin Tian, Luk Chiu

The use of a light-scattering particle size distribution analyzer has been shown to be a convenient method for characterizing the particle size distribution of parenteral emulsions. However, the concentrations of the samples used were found to have a major impact on the …

gb, us (code pays fourni par la source)

Sustained local drug delivery to the arterial wall via biodegradable microspheres

Vishva Dev, Neal L Eigler, Michael C. Fishbein, Youqin Tian et autres

This study was designed to evaluate the feasibility of applying locally delivered polylactic acid microspheres for drug delivery to the arterial wall. To study drug persistence, rhodamine-loaded microspheres were infused into one carotid artery of 14 rabbits and plain rhodamine solution into …

us (code pays fourni par la source)