Jignesh Patel

Dual pathway inhibition with faricimab for previously treated neovascular age-related macular degeneration and diabetic macular oedema: guidance from a UK panel of retina specialists

Louise Downey, Sobha Sivaprasad, Ramandeep Chhabra, Clare Bailey et autres

BACKGROUND/OBJECTIVES: Some eyes with neovascular age-related macular degeneration (nAMD) and centre-involving diabetic macular oedema (DMO) fail to respond sufficiently or lose response over time to standard of care intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy. This paper explores clinical scenarios for switching …

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Stereotactic radiotherapy for neovascular age-related macular degeneration (STAR): a pivotal, randomised, double-masked, sham-controlled device trial

Timothy L. Jackson, Riti Desai, Hatem A Wafa, Yanzhong Wang et autres

BACKGROUND: Neovascular age-related macular degeneration (nAMD) is a leading cause of blindness. The first-line therapy is anti-vascular endothelial growth factor (anti-VEGF) agents delivered by intravitreal injection. Ionising radiation mitigates key pathogenic processes underlying nAMD, and therefore has therapeutic potential. STAR aimed to …

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Beneficial Effect Of Manilkara Hexandra Extract On Letrozole-Induced Polycystic Ovary Syndrome (PCOS) In Female Rats

Jignesh Patel, Adarsh V. Kevdiya

This study inves gates the therapeu c poten al of the methanolic extract of Manilkara hexandra leaves (MEMH) in managing letrozole-induced polycys c ovary syndrome (PCOS) in female rats. The rats were divided into six groups, with varying letrozole and MEMH doses …

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Dual pathway inhibition with faricimab for previously treated neovascular age-related macular degeneration and diabetic macular oedema: Guidance from a UK panel of retina specialists

Louise Downey, Sobha Sivaprasad, Ramandeep Chhabra, Clare Bailey et autres

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Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery

Mark Edwards, Gordon Forbes, Neil Walker, Dion Morton et autres

INTRODUCTION: Postoperative morbidity and mortality in patients undergoing major emergency gastrointestinal surgery are a major burden on healthcare systems. Optimal management of perioperative intravenous fluids may reduce mortality rates and improve outcomes from surgery. Previous small trials of cardiac-output guided haemodynamic therapy …

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Protective Effect of Nelumbo nucifera Plant on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Rats

Jignesh Patel, Monika Kumbhani, Morvi M. Raval

Objectives Ulcerative colitis is a global disease with increasing incidence and worldwide prevalence. So this study was undertaken to observe antiulcerative colitis activity of ethanolic extract of seeds of Nelumbo nucifera plant on dextran sodium sulfate (DSS)-induced ulcerative colitis in rats. Materials …

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Comparison of WiFi, Bluetooth and Redtacton

Saurabh Pokharkar, Gaurav Vanjara, Yash Bansode, Jignesh Patel

Human space Network (HAN) technology is within the initial stage of development, and numerous analysis challenges ought to be overcome for it to be accepted wide. The transmission media in Han is that the flesh that has the potential to support Redtacton …

Patient-reported outcomes in the RELIGHT clinical trial of ranibizumab in diabetic macular oedema

Usha Chakravarthy, Ian Pearce, Sanjiv Banerjee, Ben Burton et autres

BACKGROUND/AIMS: The RELIGHT clinical trial used an individualised treatment regimen of ranibizumab to treat diabetic macular oedema (DMO). We report findings from two patient-reported outcome instruments. METHODS: The National Eye Institute Visual Function Questionnaire (NEI-VFQ) was administered before starting treatment (M0) and …

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A Survey on Cloud Security Issues

Foram Suthar, Samarat V.O. Khanna, Jignesh Patel

International Journal of Computer Sciences and Engineering (A UGC Approved and indexed with DOI, ICI and Approved, DPI Digital Library) is one of the leading and growing open access, peer-reviewed, monthly, and scientific research journal for scientists, engineers, research scholars, and academicians, …

Intracoronary optical coherence tomography catheter for fiber-optic endoscopic trans-vitreal optical coherence tomography of the retina to diagnose peripheral retinal tears

Chrishan D. Gunasekera, Jignesh Patel, Peter Thomas, Philip Alexander

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Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial

Sobha Sivaprasad, A Toby Prevost, Joana C. Vasconcelos, Amy Riddell et autres

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A multidisciplinary team approach to efficient breast cancer diagnosis.

Mary Cianfrocca, Melissa Shelby, Shefali Birdi, Stephanie Costa Byrum et autres

88 Background: System inefficiencies result in delayed breast cancer diagnoses. Inefficiencies include any non-value added steps between symptom onset/imaging abnormality to cancer diagnosis and treatment. Diagnostic delays can lead to more advanced disease and may negatively impact survival. Further, optimizing the efficiency …

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