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Profil bibliographique

J Germany

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

6Publications signalées
333Citations signalées
0Affiliations récentes

Les domaines associés

HIV Research and TreatmentHIV/AIDS drug development and treatmentHIV/AIDS Research and InterventionsDNA and Nucleic Acid ChemistryGlycosylation and Glycoproteins Research

Les publications récentes

Accès ouvert 1991 article OpenAlex

Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases alpha, beta, and gamma by the 5'-triphosphates of carbovir, 3'-azido-3'-deoxythymidine, 2',3'-dideoxyguanosine and 3'-deoxythymidine. A novel RNA template for the evaluation of antiretroviral drugs

William B. Parker, E. Lucile White, Sue C. Shaddix, L. J. N. Ross et autres

Carbovir (the carbocyclic analog of 2'-3'-didehydro-2',3'-dideoxyguanosine) is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) replication. Assays were developed to assess the mechanism of inhibition by the 5'-triphosphate of carbovir of HIV-1 reverse transcriptase using either RNA or DNA templates …

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133 citations Journal of Biological Chemistry
Accès ouvert 1991 article OpenAlex

Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element

Timothy A. Vickers, Brenda F. Baker, P. Dan Cook, Maryann C. Zounes et autres

All human immunodeficiency virus mRNAs contain a sequence known as TAR (trans-activating responsive sequence). The TAR element forms a stable RNA stem-loop structure which binds the HIV tat (trans-activator) protein and mediates increased viral gene expression. In principle, molecules which bind to …

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133 citations Nucleic Acids Research

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