Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7
Shaoyi Sun, Sultan Chowdhury, Ivan Hemeon, Abid Hasan et autres
0 citationsBioorganic & Medicinal Chemistry Letters
Daniel F. Ortwine
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120Publications signalées
4849Citations signalées
0Affiliations récentes
Domaines associés
Synthesis and biological activityComputational Drug Discovery MethodsQuinazolinone synthesis and applicationsSynthesis and Biological EvaluationSynthesis and Characterization of Heterocyclic Compounds
Publications récentes
Machine Learning ADME Models in Practice: Four Guidelines from a Successful Lead Optimization Case Study
Alexander Rich, Yvonne Chan, Benjamin Birnbaum, Kamran Haider et autres
12 citationsACS Medicinal Chemistry Letters
Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors
Marc Kschonsak, Christine C. Jao, Alexis Rohou, Philippe Bergeron et autres
28 citationseLife
Author response: Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors
Marc Kschonsak, Christine C. Jao, Alexis Rohou, Philippe Bergeron et autres
0 citations
CryoEM reveals unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors
Marc Kschonsak, Christine C. Jao, Christopher P. Arthur, Alexis Rohou et autres
0 citationsbioRxiv (Cold Spring Harbor Laboratory)
CCDC 2167969: Experimental Crystal Structure Determination
Jun Liang, Robert A. Blake, Jae H. Chang, Stephen Daly et autres
0 citationsThe Cambridge Structural Database
Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer
Jun Liang, Jun Li, Robert A. Blake, Jae H. Chang et autres
10 citationsBioorganic & Medicinal Chemistry Letters
Taking away PAIN: enabling new structures of the Nav1.7 sodium channel by cryo-EM
Christine C. Jao, Christopher P. Arthur, Alexis Rohou, Marc Kschonsak et autres
0 citationsActa Crystallographica Section A Foundations and Advances
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer
Jun Liang, Jason R. Zbieg, Robert A. Blake, Jae H. Chang et autres
141 citationsJournal of Medicinal Chemistry
GDC-9545 in complex with estrogen receptor alpha
James R. Kiefer, Maia Vinogradova, Jun Liang, X. Wang et autres
1 citationWorldwide Protein Data Bank
CCDC 2074641: Experimental Crystal Structure Determination
Brian S. Safina, Steven J. McKerrall, Shaoyi Sun, Chien‐An Chen et autres
0 citationsThe Cambridge Structural Database
Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310
Brian S. Safina, Steven J. McKerrall, Shaoyi Sun, Chien‐An Chen et autres
43 citationsJournal of Medicinal Chemistry
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