Bu-Miin Huang

Combination treatment of cordycepin and radiation induces apoptosis accompanied by protective autophagy in TM3 mouse Leydig progenitor cells

Yuyan Lan, Yi-Ping Lee, Wei-Ru Huang, Chunying Yu et autres

Leydig cells are anatomically located in the testicular interstitial tissue, and their main function is to produce and secrete testosterone and indirectly support spermatogenesis. We previously reported that the combination treatment of cordycepin and radiation can effectively induce Leydig tumor cell apoptosis …

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Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes

Ming‐Min Chang, Chang-Ni Lin, Cheng-Chieh Fang, Marcelo Chen et autres

Plants containing aristolochic acids (AA) are nephrotoxins. Glycine N-methyltransferase (GNMT) acts to bind environmental toxins such as benzo(a)pyrene and aflatoxin B1, translocate into nucleus, and alter hepatic metabolism. This study aims to determine the role of GNMT in AA-induced nephropathy. We established …

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Cordycepin enhances cisplatin apoptotic effect through caspase/MAPK pathways in human head and neck tumor cells

Bu-Miin Huang, Yinghui Chen, Jo-Yu Wang, Bo‐Syong Pan et autres

PURPOSE: The present study aims to investigate whether the combination treatment of cordycepin (an extracted pure compound from Cordyceps sinensis) and cisplatin (a platinum-based chemotherapy drug) has better apoptotic effect in head and neck squamous cell carcinoma (HNSCC). METHODS: The apoptotic influences …

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Identification and Cytoprotective Function of a Novel Nestin Isoform, Nes-S, in Dorsal Root Ganglia Neurons

Peng-Han Su, Chih‐Cheng Chen, Ya-Fan Chang, Zong-Ruei Wong et autres

In this study, the first nestin isoform, Nes-S, was identified in neurons of dorsal root ganglia (DRG) of adult rats. Nes-S cannot form filaments by itself in cytoplasmic intermediate filament-free SW13 cells. Instead, it co-assembles into filaments with vimentin when transfected into …

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Apoptotic mechanism of paclitaxel‐induced cell death in human head and neck tumor cell lines

Jenn Ren Hsiao, Sew-Fen Leu, Bu-Miin Huang

BACKGROUND: Paclitaxel (taxol) is clinically used to treat various human tumors. However, the cellular and molecular mechanism regarding apoptotic effect of paclitaxel on head and neck squamous cell carcinoma (HNSCC) remains elusive. METHODS: The apoptotic effect and the mechanism of paclitaxel on …

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EFFECTS OFTREMELLA MESENTERICAON STEROIDOGENESIS IN MA-10 MOUSE LEYDIG TUMOR CELLS

Hui‐Chen Lo, Yu-Wei Chen, Cheng-Yen Chien, Chi‐Yu Tseng et autres

Tremella mesenterica (TM), a yellow jelly mushroom, has been traditionally used as food and crude medicine to improve several kinds of symptoms in Chinese society for a long time. Recent studies have illustrated that the fractions of fruiting bodies of TM exhibit …

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In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells

Chih-Chao Hsu, Yuan‐Li Huang, Shaw‐Jenq Tsai, Chia-Chin Sheu et autres

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