Human Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASC42, a Novel Farnesoid X Receptor Agonist
4 citationsDrugs in R&D
Handan He
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67Publications signalées
3062Citations signalées
1Affiliations récentes
Institutions déclarées
Domaines associés
Pharmacogenetics and Drug MetabolismDrug Solubulity and Delivery SystemsDrug Transport and Resistance MechanismsAnalytical Chemistry and ChromatographyStatistical Methods in Clinical Trials
Publications récentes
A phase 2 study of ASC42, a novel farnesoid X receptor (FXR) agonist, in combination with PEGylated interferon (PEG-IFN) and entecavir(ETV) in chronic hepatitis B patients with 12-week treatment
Jinlin Hou, Qianguo Mao, Jing Yuan, Gengwang Hu et autres
0 citationsJournal of Hepatology
Abstract 6360: In vivo antitumor efficacy evaluation of ASC63, an oral small molecule PD-L1 inhibitor, in a humanized mouse tumor model
0 citationsCancer Research
CCDC 2248014: Experimental Crystal Structure Determination
François Baur, David A. Beattie, David Beer, David Bentley et autres
0 citationsThe Cambridge Structural Database
ALT flares were linked to HBsAg reduction, seroclearance and seroconversion: interim results from a phase IIb study in chronic hepatitis B patients with 24-week treatment of subcutaneous PD-L1 Ab ASC22 (Envafolimab) plus nucleos (t)ide analogs
Guiqiang Wang, Yimin Cui, Yao Xie, Qianguo Mao et autres
20 citationsJournal of Hepatology
Abstract 5529: In vivo efficacy evaluation of ASC61, an oral PD-L1 inhibitor, in two tumor mouse models
3 citationsCancer Research
Abstract 5466: Efficacy of ASC60, an oral fatty acid synthase inhibitor, in two tumor mouse models
0 citationsCancer Research
IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies
Amais Ahmad, Xavier Pépin, Leon Aarons, Yuya Wang et autres
40 citationsEuropean Journal of Pharmaceutics and Biopharmaceutics
Ribociclib Drug‐Drug Interactions: Clinical Evaluations and Physiologically‐Based Pharmacokinetic Modeling to Guide Drug Labeling
Tanay S. Samant, Felix Huth, Kenichi Umehara, Hilmar Schiller et autres
52 citationsClinical Pharmacology & Therapeutics
Model‐Informed Drug Development for Everolimus Dosing Selection in Pediatric Infant Patients
François Pierre Combes, Heidi J. Einolf, Neva Coello, Tycho Heimbach et autres
17 citationsCPT Pharmacometrics & Systems Pharmacology
ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium
Philip Bransford, Jack Cook, Manish Gupta, Sebastian Haertter et autres
32 citationsMolecular Pharmaceutics
Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities
Erica L. Bradshaw, Mary E. Spilker, Richard Zang, Loveleena Bansal et autres
92 citationsCPT Pharmacometrics & Systems Pharmacology
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