Haruhisa Mita

Hypersensitivity to intravenous succinate corticosteroids in patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease

Masami Taniguchi, Atsuhiko Sato, Haruhisa Mita

Although there are many case reports of asthma exacerbations with intravenous corticosteroids, especially hydrocortisone succinate, in nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD), the frequency and mechanism remain unclear. We hypothesized that N-ERD patients are potentially hypersensitive to succinates, especially succinate corticosteroids, based …

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Aspirin-exacerbated respiratory disease (AERD): Current understanding of AERD

Masami Taniguchi, Chihiro Mitsui, Hiroaki Hayashi, Emiko Ono et autres

The characteristics in AERD are severe adult-onset asthma, eosinophilic rhinosinusitis with nasal polyposis, and CysLT overproduction. The cause of AERD have remained unclear, however the decrease in the production of PGE2 caused by the reduction in COX-2 activity is considered to main …

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P-Selectin is a Key Molecule Underlying the Pathophysiology of Aspirin- Exacerbated Respiratory Disease

Chihiro Mitsui, 景一 梶原, Hiroaki Hayashi, Jun Ito et autres

Recently, the evidence for platelet association with allergic diseases has been established by many researches. Activated platelets contribute to airway hyper reactivity, bronchoconstriction, airway inflammation and airway remodeling in asthmatic patients. We aimed to clarify platelet activation and key molecules on platelets, …

Platelet activation markers overexpressed specifically in patients with aspirin-exacerbated respiratory disease

Chihiro Mitsui, 景一 梶原, Hiroaki Hayashi, Jun Ito et autres

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薬物アレルギー III.NSAIDs過敏症

Taniguchi Masami, Higashi Noritaka, Mitsui Chihiro, Ono Emiko et autres

Exercise-Induced Bronchoconstriction in Children with Asthma: Is There an Association with Urinary Leukotriene E 4 or Exhaled Nitric Oxide

Chikako Motomura, Hiroshi Odajima, Noritaka Higashi, Junichiro Tezuka et autres

Cysteinyl leukotrienes (LT) and airway inflammation are thought to affect exercise-induced bronchoconstriction (EIB). The aim of this study was to investigate the relations between EIB and urinary leukotriene E 4 (LTE 4 ) levels and other noninvasive measures of airways inflammation markers …

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Aspirin-Intolerant Asthma (AIA) Assessment Using the Urinary Biomarkers, Leukotriene E4 (LTE4) and Prostaglandin D2 (PGD2) Metabolites

Noritaka Higashi, Masami Taniguchi, Haruhisa Mita, Hiromichi Yamaguchi et autres

The clinical syndrome of aspirin-intolerant asthma (AIA) is characterized by aspirin/nonsteroidal anti-inflammatory drug intolerance, bronchial asthma, and chronic rhinosinusitis with nasal polyposis. AIA reactions are evidently triggered by pharmacological effect of cyclooxygenase-1 inhibitors. Urine sampling is a non-invasive research tool for time-course …

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Urinary tetranor-PGDM concentrations in aspirin-intolerant asthma and anaphylaxis

Noritaka Higashi, Haruhisa Mita, Hiromichi Yamaguchi, Yuma Fukutomi et autres

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Urinary concentrations of 15‐epimer of lipoxin A4are lower in patients with aspirin‐intolerant compared with aspirin‐tolerant asthma

Hiromichi Yamaguchi, Noritaka Higashi, Haruhisa Mita, Emiko Ono et autres

BACKGROUND: Although an abnormality in arachidonic acid metabolism may be responsible for aspirin-intolerant asthma (AIA), there is little knowledge about the concentrations of urinary lipoxin A(4) (LXA(4)) and the 15-epimer of LXA(4) (15-epi-LXA(4)) in relation to asthma severity in AIA subjects. OBJECTIVE: …

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Immunoglobulin E oligomers identified in blood components activate mast cells: relevance to anaphylactic transfusion reaction

TAKAAKI K. ABE, Chieko Matsumoto, Eiko Shimada, Toshio Mazda et autres

BACKGROUND: In most cases of anaphylactic transfusion reaction, the mechanisms underlying its development are unclear. We found a donor whose transfused blood components were implicated in two cases of anaphylactic transfusion reaction, and we found that the donor plasma showed mast cell …

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Increase in Salivary Cysteinyl-Leukotriene Concentration in Patients with Aspirin-Intolerant Asthma

Emiko Ono, Masami Taniguchi, Noritaka Higashi, Haruhisa Mita et autres

BACKGROUND: Cysteinyl-leukotrienes (CysLTs; LTC4, LTD4, and LTE4) play a considerable role in the pathophysiology of aspirin-intolerant asthma (AIA). Saliva has recently been validated as novel, simple, and noninvasive method for investigating inflammation in patients with asthma. The aim of this study is …

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「気道炎症モニタリングの一般臨床応用化:新しい喘息管理目標の確立に関する研究」-呼気中の脂質メデイエータ測定の喘息管理における臨床応用に関するデータ集積-

Kazuo Akiyama, Takahiro Tsuburai, Haruhisa Mita, Higashi Noritaka et autres