Anne-Cornélie JM de Pont

Attributable mortality of ventilator-associated pneumonia

Anne-Cornélie JM de Pont

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Cholinesterase inhibitor treatment in patients with delirium

Anne-Cornélie JM de Pont, Michael A van Geer, Marcus J. Schultz

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Spontaneous hypothermia on intensive care unit admission is a predictor of unfavorable neurological outcome in patients after resuscitation: an observational cohort study

Alexander W. den Hartog, Anne-Cornélie JM de Pont, Laure B M Robillard, Jan M. Binnekade et autres

INTRODUCTION: A large number of patients resuscitated for primary cardiac arrest arrive in the intensive care unit (ICU) with a body temperature < 35.0 degrees C. The aim of this observational cohort study was to determine the association between ICU admission temperature …

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Extracorporeal treatment of intoxications

Anne-Cornélie JM de Pont

PURPOSE OF REVIEW: The purpose of this article is to provide the critical care clinician with a comprehensive review of the indications for extracorporeal elimination of toxic substances, to summarize the different techniques and the intoxications for which these techniques are suitable. …

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Pharmacokinetics and pharmacodynamics of danaparoid during continuous venovenous hemofiltration: a pilot study

Anne-Cornélie JM de Pont, Jorrit-Jan Hofstra, Derk R Pik, Joost C.M. Meijers et autres

BACKGROUND: In patients with suspected heparin-induced thrombocytopenia (HIT) who need renal replacement therapy, a nonheparin anticoagulant has to be chosen to prevent thrombosis in the extracorporeal circuit. Danaparoid, a low-molecular-weight heparinoid consisting of heparan sulphate, dermatan sulphate, and chondroitin sulphate, is recommended …

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The effects of continuous venovenous hemofiltration on coagulation activation

Catherine S. C. Bouman, Anne-Cornélie JM de Pont, Joost C.M. Meijers, Kamran Bakhtiari et autres

INTRODUCTION: The mechanism of coagulation activation during continuous venovenous hemofiltration (CVVH) has not yet been elucidated. Insight into the mechanism(s) of hemostatic activation within the extracorporeal circuit could result in a more rational approach to anticoagulation. The aim of the present study …

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Timing of drotrecogin alfa (activated) treatment in severe sepsis.

Goda Choi, Anne-Cornélie JM de Pont, Marcus J. Schultz

The effect of the timing of drotrecogin alfa (activated) (DrotAA) treatment on the outcome of severe sepsis was recently evaluated, using the integrated clinical trial database INDEPTH. The evaluation demonstrated an association between earlier treatment (i.e. treatment within 24 hours of the …

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Recombinant human activated protein C resets thrombin generation in patients with severe sepsis - a case control study.

Anne-Cornélie JM de Pont, Kamran Bakhtiari, Barbara A. Hutten, Evert de Jonge et autres

INTRODUCTION: Recombinant human activated protein C (rhAPC) is the first drug for which a reduction of mortality in severe sepsis has been demonstrated. However, the mechanism by which this reduction in mortality is achieved is still not clearly defined. The aim of …

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