Yu‐zhong Duan

Interaction between the BDNF rs11030101 genotype and job stress on cognitive empathy

Yu‐zhong Duan, Yuling Li, Hanqi Yun, Andrew M. Kaplan et autres

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The Efficacy and Safety of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Combined With Thymosin in Advanced Non-Small Cell Lung Cancer Patients Harboring Active Epidermal Growth Factor Receptor Mutations

Yongdong Feng, Guangkuo Zhu, Song Lang, Guanghui Li et autres

Objective To explore the efficacy and safety of EGFR-TKI combined with thymosin therapy in advanced non-small cell lung cancer (NSCLC) patients harboring active EGFR mutations. Methods Patients confirmed as advanced NSCLC with active EGFR mutations were recruited from August 2008 to July …

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Analysis of Work-related Stress of Soldiers and Its Influencing Factors under Special Military Environment

Ke Li, Lei Shi, Xiaotong Lou, Yu‐zhong Duan et autres

Background: As a special kind of profession, the work-related stress of military personnel always is a concern of experts and scholars from all walks of life, but the work-related stress of soldiers under special environment is always ignored. Aim: This study investigated …

Prevention and control of coronavirus disease 2019 in Grade-III Class-A hospitals outside of Wuhan

Jianwen Gu, Hong-Jiang Wang, Quanxing Shi, Yang Tao et autres

Now, a novel coronavirus epidemic has posed a major threat to human health. Medical staff face a high risk of occupational exposure at very early stages of an epidemic. Once the medical staff are infected, it will greatly affect the “fighting capacity” …

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Concurrent EGFR-TKI and Thoracic Radiotherapy as First-Line Treatment for Stage IV Non-Small Cell Lung Cancer Harboring EGFR Active Mutations

Linpeng Zheng, Yanmei Wang, Zihan Xu, Qiao Yang et autres

LESSONS LEARNED: This single-arm, phase II study shows that concurrent EGFR-tyrosine kinase inhibitor plus thoracic radiotherapy as the first-line treatment for stage IV non-small cell lung cancer harboring EGFR active mutations provides long-term control for the primary lung lesion, and 1-year progression-free …

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Clinical benefits of Livin peptide-loaded DCs/CIKs combined with chemotherapy in advanced non-small cell lung cancer.

Luping Zhang, Zihan Xu, Xiewan Chen, Yu‐zhong Duan et autres

Previous studies showed that Livin, a member of inhibitors of apoptosis protein (IAP), played an important role in drug and radiation resistance. When the expression of Livin was blocked, the sensitivity to both chemotherapy and radiotherapy was improved in lung cancer cells. …

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Novel treatment strategies for patients with HER2‑positive breast cancer who do not benefit from current targeted therapy drugs (Review)

Nan Jiang, Jingjing Lin, Jun Wang, Bei‐Ning Zhang et autres

Human epidermal growth factor receptor‑2 positive breast cancer (HER2+ BC) is characterized by a high rate of metastasis and drug resistance. The advent of targeted therapy drugs greatly improves the prognosis of HER2+ BC patients. However, drug resistance or severe side effects …

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Clinical benefit from EGFR-TKI plus ginsenoside Rg3 in patients with advanced non-small cell lung cancer harboring EGFR active mutation

Yan Li, Yanmei Wang, Kai Niu, Xiewan Chen et autres

// Yan Li 1, * , Yanmei Wang 1, * , Kai Niu 1 , Xiewan Chen 2 , Liqin Xia 1 , Dingxi Lu 2 , Rui Kong 1 , Zhengtang Chen 1 , Yuzhong Duan 1 , Jianguo Sun 1 …

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Feasibility study of DCs/CIKs combined with thoracic radiotherapy for patients with locally advanced or metastatic non-small-cell lung cancer

Luping Zhang, Yanmei Xu, Shen Jie, Feng He et autres

BACKGROUND: The combination of dendritic cells (DCs) and cytokine-induced killer cells (CIKs) can induce the anti-tumor immune response and radiotherapy may promote the activity. We aimed to explore the feasibility of DCs/CIKs combined with thoracic radiotherapy (TRT) for patients with locally advanced …

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Plasma miRNAs in predicting radiosensitivity in non-small cell lung cancer

Xu Chen, Yanmei Xu, Xingyun Liao, Luping Zhang et autres

BACKGROUND: Radioresistance of thoracic radiotherapy is a major bottleneck in the treatment of non-small cell lung cancer (NSCLC). Until now, there have been no effective biomarkers to predict the radiosensitivity. PURPOSES: Based on miRNA profile screened from NSCLC cell lines with different …

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IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma

Weipeng Zhao, Jun Wang, Bo Zhu, Yu‐zhong Duan et autres

Lymphangiogenesis is not only involved in the processes of embryonic development, tissue repair and chronic inflammation, but also in tumor lymphatic metastasis. Metastatic tumor cells spreading through lymphatic vessels occur in non-small cell lung carcinoma (NSCLC), with regional lymph node metastasis often …

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A Study Design: Concurrent EGFR-TKI and Thoracic Radiotherapy as Firstline Treatment of Stage IV NSCLC Patients with EGFR Active Mutations (CERTAIN Study)

Yanmei Wang, Yu‐zhong Duan, Rong-Xia Liao, Yan Li et autres

Lung cancer is a common malignant tumor with high morbidity and mortality worldwide; more than 70 percent of patients are diagnosed with advanced disease. Nowadays, chemotherapy with concurrent thoracic radiotherapy (TRT) has been proven effective in stage IV NSCLC. Epidermal growth factor …