Teiryo Maeda

Low levels of serum ferritin and moderate transferrin saturation lead to adequate hemoglobin levels in hemodialysis patients, retrospective observational study

Chie Ogawa, Ken Tsuchiya, Naohisa Tomosugi, Fumiyoshi Kanda et autres

BACKGROUND: Optimal iron levels in patients on hemodialysis are currently unknown, and a higher level than that for the healthy population is usually set for such patients considering the use of erythropoiesis-stimulating agents or the occurrence of chronic inflammation. However, excessive iron …

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FP655LOW LEVELS OF SERUM FERRITIN WITH MODERATE LEVEL OF TRANSFERRIN SATURATION MAINTAINS ADEQUATE HEMOGLOBIN IN HEMODIALYSIS PATIENTS

Chie Ogawa, Ken Tsuchiya, Fumiyoshi Kanda, Kunimi Maeda et autres

Introduction and Aims: Control of iron storage is an important therapeutic measure for anemia in hemodialysis (HD) patients. The required amount of iron increases in erythropoiesis stimulating agent therapy. However, excess iron induces the production of hepcidin25 (Hep25), thereby reducing the efficiency …

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Hepcidin-25, Mean Corpuscular Volume, and Ferritin as Predictors of Response to Oral Iron Supplementation in Hemodialysis Patients

Kazuya Takasawa, Chikako Takaeda, Teiryo Maeda, Norishi Ueda

The benefit of oral iron therapy (OIT) and factors predictive of OIT response are not established in hemodialysis (HD) patients with iron deficiency anemia (IDA). We examined the values of hepcidin-25, mean corpuscular volume (MCV), and ferritin as predictors of OIT response. …

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Regulation of Hepcidin-25 by Short- and Long-Acting rhEPO May Be Dependent on Ferritin and Predict the Response to rhEPO in Hemodialysis Patients

Kazuya Takasawa, Naohisa Tomosugi, Chikako Takaeda, Teiryo Maeda et autres

BACKGROUND/AIMS: We examined whether regulation of hepcidin-25 by short- or long-acting recombinant human erythropoietin (rhEPO) is dependent on ferritin and predicts the response to rhEPO in hemodialysis (HD) patients. METHODS: Two studies with rhEPO were performed in 9 HD patients with a …

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Low Levels of Serum Ferritin Lead to Adequate Hemoglobin Levels and Good Survival in Hemodialysis Patients

Chie Ogawa, Ken Tsuchiya, Fumiyoshi Kanda, Teiryo Maeda

BACKGROUND: The optimal level of serum ferritin (s-ft) for anemia control and good survival in hemodialysis (HD) patients remains unclear. A 10-year survey was performed to clarify the appropriate quantities of s-ft and investigate the relationships among s-ft, transferrin saturation (TSAT), and …

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Position Statement from ADA/AACE/EASD/TES in Response to a Recently Published Letter to the Editor in The Lancet and an Editorial Addressing the Israeli-Palestinian Fighting in Gaza

Wei Deng, Yile Ren, Xuebing Feng, Genhong Yao et autres

Contents Vol. 40, 2014

Wei Deng, Yile Ren, Xuebing Feng, Genhong Yao et autres

Acknowledgement to the Reviewers

Wei Deng, Yile Ren, Xuebing Feng, Genhong Yao et autres

Randomized Controlled Open-Label Trial of Vitamin E-Bonded Polysulfone Dialyzer and Erythropoiesis-Stimulating Agent Response

Tsutomu Sanaka, Takahiro Mochizuki, Eriko Kinugasa, Eiji Kusano et autres

BACKGROUND AND OBJECTIVES: A 1-year multicenter prospective randomized controlled study was conducted on the effects of vitamin E-bonded polysulfone dialyzers on erythropoiesis-stimulating agent response in hemodialysis patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Major inclusion criteria were use of high-flux polysulfone dialyzers with …

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Oral iron administration is benefical for anemia with smaller mean corpuscular volume (mcv) in hemodialysis patients with low hepcidin-25 levels

Kazuya Takasawa, Chikako Takaeda, Norishi Ueda, M. Higuchi et autres

Oral iron administration (OIA) is little benefit, and I.V. iron injection (IVI) is recommended. IVI increases high serum ferritin (ferr) levels, increaseing serum hepcidin-25(hepc) levels, which inhibits intestinal iron absorption. In a state of low hepc levels, intestinal iron absorption can be …

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A prospective multicenter study of vitamin E-bonded polysulfone membrane for erythropoiesis-stimulating agents in hemodialysis patients

Takahiro Mochizuki, Eriko Kinugasa, Eiji Kusano, Shigeru Ohwada et autres

【目的】ビタミンE固定化ポリスルフォン膜ダイアライザ（VPS-HA）が，血液透析患者の貧血や，貧血治療薬（ESA）の投与量に影響を与えるか否かを検討した．【方法】主要なエントリー基準は，機能分類IV型ポリスルフォン（PS）膜を3か月以上使用し，直近3か月はTSAT 20％以上で，ESA製剤の変更がなく，ヘモグロビン（Hb）値は10.0g/dL以上12.0g/dL未満を満たす患者とした．研究参加は48施設で，305症例がエントリーされた．エントリー患者を，VPS-HAに変更する群（151名）と，従来のIV型PS膜を継続する群（154名）の2群に分け（中央登録方式），研究開始時のHb値を維持（10.0≦Hb＜11.0g/dLおよび11.0≦Hb＜12.0g/dL）するESA投与量を主要評価項目とした．その評価指標としてエリスロポエチン抵抗性指数（erythropoietic resistance index：ERI）を用いた．【結果】研究は1年間実施された．目標Hb値10.0≦Hb＜11.0g/dLの範囲では差はなかったが，目標Hb値11.0≦Hb＜12.0g/dLの範囲で，VPS-HA群はIV型PS膜群に比して良好なESA反応性を示した．とくにVPS-HA群のDarbepoetin alfa（DA）投与例では，8か月以降で開始時と比較して統計的有意差をもってERIが減少していた．またIV型PS膜群のrHuEPO投与症例では，統計的に5，7，10か月で，開始時と比較してERIが増加していた．VPS-HAとIV型PS膜の群間比較では，11か月目でVPS-HA群のDA投与例でIV型PS膜群に比して，ERIが有意に減少していた．【結語】目標Hb値11.0≦Hb＜12.0g/dLの範囲で，ビタミンE固定化膜は，IV型PS膜に比べてDA投与量が減少しており，ESA投与量軽減効果が期待できる（UMIN試験ID：UMIN000001285)．

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Role of hepcidin-25 for regulation of iron metabolism in anemia associated with diabetic patients on hemodialysis

Kazuya Takasawa, Chikako Takaeda, M. Higuchi, Teiryo Maeda et autres